High normal sized CGG repeat on the FMR1 gene reduces live birth rates after in vitro fertilization in Han Chinese

•Women with high normal FMR1 allele have a higher risk of reduced live birth rates.•Enhanced screening for fragile X syndrome in women of childbearing age in China.•Association between the FMR1 genotype and fertility merits further research. Substantial evidence now suggests an association between t...

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Veröffentlicht in:	Gene 2022-04, Vol.819, p.146204-146204, Article 146204
Hauptverfasser:	Zhou, Xuanyou, Shi, Weihui, Ye, Mujin, Chen, Songchang, Xu, Naixin, Xu, Chenming
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous - genetics Adult Alleles Asians - genetics Female Fertilization in Vitro FMR1 gene Fragile X Mental Retardation Protein - genetics Fragile X screening Fragile X Syndrome - genetics FXPOI Genetic Association Studies Genetic Testing - methods Humans IVF Live Birth - genetics Pregnancy Reproductive failure Reproductive Medicine Retrospective Studies Trinucleotide Repeats
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Zusammenfassung:	•Women with high normal FMR1 allele have a higher risk of reduced live birth rates.•Enhanced screening for fragile X syndrome in women of childbearing age in China.•Association between the FMR1 genotype and fertility merits further research. Substantial evidence now suggests an association between the FMR1 genotype and female fertility. The aim of this study was to determine whether a high normal FMR1 allele (35–54 repeats) affects in vitro fertilization (IVF) outcomes in Chinese women. A total of 120 women with 210 IVF cycles were retrospectively recruited in this study. The patients were divided into two groups based on the FMR1 repeat lengths at allele 2 (normal repeat group:
ISSN:	0378-1119 1879-0038
DOI:	10.1016/j.gene.2022.146204