Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation
Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to...
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| Veröffentlicht in: | International journal of hematology 2022-04, Vol.115 (4), p.534-544 |
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| creator | Onizuka, Makoto Fujii, Nobuharu Nakasone, Hideki Ogata, Masao Atsuta, Yoshiko Suzuki, Ritsuro Uchida, Naoyuki Ohashi, Kazuteru Ozawa, Yukiyasu Eto, Tetsuya Ikegame, Kazuhiro Nakamae, Hirohisa Inoue, Masami Fukuda, Takahiro |
| description | Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to 2009. Among 13,573 eligible patients, 535 experienced NIPCs (3.9%). Multivariate analysis identified high recipient age (60 + years: HR 1.85,
P
= 0.003), HLA mismatch (HR 1.61,
P
|
| doi_str_mv | 10.1007/s12185-021-03282-9 |
| format | Article |
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P
= 0.003), HLA mismatch (HR 1.61,
P
< 0.001), female to male HSCT (HR 1.54,
P
< 0.001), and unrelated bone marrow transplantation (UR-BMT) (HR 3.88,
P
< 0.001) as significantly associated with an increased risk of NIPCs. In contrast, a non-total body irradiation (TBI) regimen with reduced intensity conditioning (RIC) were associated with a decreased risk of NIPCs compared with a cyclophosphamide (CY) + TBI regimen (busulfan + CY: HR 0.67,
P
= 0.009, other non-TBI: HR 0.46,
P
< 0.001), fludarabine-based RIC (HR 0.52,
P
< 0.001), and other RIC (HR 0.42,
P
= 0.003). The mortality rate was significantly worse for patients with NIPCs than those without (HR 1.54, 71
P
< 0.001). This large-scale retrospective study suggests that both allo-reactions to donor cells and conditioning regimen toxicity contributed to NIPCs following HSCT.]]></description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-021-03282-9</identifier><identifier>PMID: 35088350</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Bone marrow ; Bone marrow transplantation ; Busulfan ; Complications ; Conditioning ; Cyclophosphamide ; Female ; Fludarabine ; Graft vs Host Disease - etiology ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Histocompatibility antigen HLA ; Humans ; Irradiation ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Oncology ; Original Article ; Prognosis ; Retrospective Studies ; Risk analysis ; Risk Factors ; Stem cell transplantation ; Stem cells ; Toxicity ; Transplantation ; Transplantation Conditioning - adverse effects</subject><ispartof>International journal of hematology, 2022-04, Vol.115 (4), p.534-544</ispartof><rights>Japanese Society of Hematology 2021</rights><rights>2021. Japanese Society of Hematology.</rights><rights>Japanese Society of Hematology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-914273d195ea6ba4c9ae6ecb6d1d9b53c76f35eb8a6ce8d5723e76e4e3bfe6ff3</citedby><cites>FETCH-LOGICAL-c399t-914273d195ea6ba4c9ae6ecb6d1d9b53c76f35eb8a6ce8d5723e76e4e3bfe6ff3</cites><orcidid>0000-0003-3864-0823</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-021-03282-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-021-03282-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35088350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onizuka, Makoto</creatorcontrib><creatorcontrib>Fujii, Nobuharu</creatorcontrib><creatorcontrib>Nakasone, Hideki</creatorcontrib><creatorcontrib>Ogata, Masao</creatorcontrib><creatorcontrib>Atsuta, Yoshiko</creatorcontrib><creatorcontrib>Suzuki, Ritsuro</creatorcontrib><creatorcontrib>Uchida, Naoyuki</creatorcontrib><creatorcontrib>Ohashi, Kazuteru</creatorcontrib><creatorcontrib>Ozawa, Yukiyasu</creatorcontrib><creatorcontrib>Eto, Tetsuya</creatorcontrib><creatorcontrib>Ikegame, Kazuhiro</creatorcontrib><creatorcontrib>Nakamae, Hirohisa</creatorcontrib><creatorcontrib>Inoue, Masami</creatorcontrib><creatorcontrib>Fukuda, Takahiro</creatorcontrib><creatorcontrib>Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation</creatorcontrib><creatorcontrib>for the Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation</creatorcontrib><title>Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description><![CDATA[Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to 2009. Among 13,573 eligible patients, 535 experienced NIPCs (3.9%). Multivariate analysis identified high recipient age (60 + years: HR 1.85,
P
= 0.003), HLA mismatch (HR 1.61,
P
< 0.001), female to male HSCT (HR 1.54,
P
< 0.001), and unrelated bone marrow transplantation (UR-BMT) (HR 3.88,
P
< 0.001) as significantly associated with an increased risk of NIPCs. In contrast, a non-total body irradiation (TBI) regimen with reduced intensity conditioning (RIC) were associated with a decreased risk of NIPCs compared with a cyclophosphamide (CY) + TBI regimen (busulfan + CY: HR 0.67,
P
= 0.009, other non-TBI: HR 0.46,
P
< 0.001), fludarabine-based RIC (HR 0.52,
P
< 0.001), and other RIC (HR 0.42,
P
= 0.003). The mortality rate was significantly worse for patients with NIPCs than those without (HR 1.54, 71
P
< 0.001). This large-scale retrospective study suggests that both allo-reactions to donor cells and conditioning regimen toxicity contributed to NIPCs following HSCT.]]></description><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Busulfan</subject><subject>Complications</subject><subject>Conditioning</subject><subject>Cyclophosphamide</subject><subject>Female</subject><subject>Fludarabine</subject><subject>Graft vs Host Disease - etiology</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Histocompatibility antigen HLA</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Toxicity</subject><subject>Transplantation</subject><subject>Transplantation Conditioning - 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etiology</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Histocompatibility antigen HLA</topic><topic>Humans</topic><topic>Irradiation</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Toxicity</topic><topic>Transplantation</topic><topic>Transplantation Conditioning - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onizuka, Makoto</creatorcontrib><creatorcontrib>Fujii, Nobuharu</creatorcontrib><creatorcontrib>Nakasone, Hideki</creatorcontrib><creatorcontrib>Ogata, Masao</creatorcontrib><creatorcontrib>Atsuta, Yoshiko</creatorcontrib><creatorcontrib>Suzuki, Ritsuro</creatorcontrib><creatorcontrib>Uchida, Naoyuki</creatorcontrib><creatorcontrib>Ohashi, Kazuteru</creatorcontrib><creatorcontrib>Ozawa, Yukiyasu</creatorcontrib><creatorcontrib>Eto, Tetsuya</creatorcontrib><creatorcontrib>Ikegame, Kazuhiro</creatorcontrib><creatorcontrib>Nakamae, Hirohisa</creatorcontrib><creatorcontrib>Inoue, Masami</creatorcontrib><creatorcontrib>Fukuda, Takahiro</creatorcontrib><creatorcontrib>Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation</creatorcontrib><creatorcontrib>for the Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onizuka, Makoto</au><au>Fujii, Nobuharu</au><au>Nakasone, Hideki</au><au>Ogata, Masao</au><au>Atsuta, Yoshiko</au><au>Suzuki, Ritsuro</au><au>Uchida, Naoyuki</au><au>Ohashi, Kazuteru</au><au>Ozawa, Yukiyasu</au><au>Eto, Tetsuya</au><au>Ikegame, Kazuhiro</au><au>Nakamae, Hirohisa</au><au>Inoue, Masami</au><au>Fukuda, Takahiro</au><aucorp>Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation</aucorp><aucorp>for the Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>115</volume><issue>4</issue><spage>534</spage><epage>544</epage><pages>534-544</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract><![CDATA[Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to 2009. Among 13,573 eligible patients, 535 experienced NIPCs (3.9%). Multivariate analysis identified high recipient age (60 + years: HR 1.85,
P
= 0.003), HLA mismatch (HR 1.61,
P
< 0.001), female to male HSCT (HR 1.54,
P
< 0.001), and unrelated bone marrow transplantation (UR-BMT) (HR 3.88,
P
< 0.001) as significantly associated with an increased risk of NIPCs. In contrast, a non-total body irradiation (TBI) regimen with reduced intensity conditioning (RIC) were associated with a decreased risk of NIPCs compared with a cyclophosphamide (CY) + TBI regimen (busulfan + CY: HR 0.67,
P
= 0.009, other non-TBI: HR 0.46,
P
< 0.001), fludarabine-based RIC (HR 0.52,
P
< 0.001), and other RIC (HR 0.42,
P
= 0.003). The mortality rate was significantly worse for patients with NIPCs than those without (HR 1.54, 71
P
< 0.001). This large-scale retrospective study suggests that both allo-reactions to donor cells and conditioning regimen toxicity contributed to NIPCs following HSCT.]]></abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>35088350</pmid><doi>10.1007/s12185-021-03282-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3864-0823</orcidid></addata></record> |
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| ispartof | International journal of hematology, 2022-04, Vol.115 (4), p.534-544 |
| issn | 0925-5710 1865-3774 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Bone marrow Bone marrow transplantation Busulfan Complications Conditioning Cyclophosphamide Female Fludarabine Graft vs Host Disease - etiology Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Histocompatibility antigen HLA Humans Irradiation Male Medical prognosis Medicine Medicine & Public Health Middle Aged Multivariate analysis Oncology Original Article Prognosis Retrospective Studies Risk analysis Risk Factors Stem cell transplantation Stem cells Toxicity Transplantation Transplantation Conditioning - adverse effects |
| title | Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation |
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