Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to...

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Veröffentlicht in:International journal of hematology 2022-04, Vol.115 (4), p.534-544
Hauptverfasser: Onizuka, Makoto, Fujii, Nobuharu, Nakasone, Hideki, Ogata, Masao, Atsuta, Yoshiko, Suzuki, Ritsuro, Uchida, Naoyuki, Ohashi, Kazuteru, Ozawa, Yukiyasu, Eto, Tetsuya, Ikegame, Kazuhiro, Nakamae, Hirohisa, Inoue, Masami, Fukuda, Takahiro
Format: Artikel
Sprache:eng
Schlagworte:
Bone marrow
Bone marrow transplantation
Busulfan
Complications
Conditioning
Cyclophosphamide
Female
Fludarabine
Graft vs Host Disease - etiology
Hematology
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Histocompatibility antigen HLA
Humans
Irradiation
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Oncology
Original Article
Prognosis
Retrospective Studies
Risk analysis
Risk Factors
Stem cell transplantation
Stem cells
Toxicity
Transplantation
Transplantation Conditioning - adverse effects
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Zusammenfassung:Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to 2009. Among 13,573 eligible patients, 535 experienced NIPCs (3.9%). Multivariate analysis identified high recipient age (60 + years: HR 1.85, P  = 0.003), HLA mismatch (HR 1.61, P  
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-021-03282-9