Nursing points of interest when nebulizing antibiotics in ventilated patients

The main advantage of nebulizing antibiotics to treat MDR-GNB VAP is the maximisation of their bactericidal effect by achieving a higher lung tissue concentration, as the difficulties of penetration of intravenous antibiotics into the lung through the alveolar-capillary barrier is overcome when using this method of administration, as well as minimizing the risk of systemic adverse events such as nephrotoxicity (Boisson et al., 2017). [...]vibrating-mesh nebulizers are small and easy to use and are the most efficient devices for administering antibiotics, as they deliver between 40 and 60% of the initial dose by producing homogeneous smaller droplets, so they are the most recommended ones (Rouby et al., 2020). Other adverse events such as cardiac arrest have been reported (Lu et al., 2011), due to obstructed expiratory filters, so, as previously described they should be substituted after each nebulization.