Hemostatic status in women with breast cancer and cardiotoxicity associated to doxorubicin-based chemotherapy – A one-year follow-up study

•Patients with breast cancer and doxorubicin-based chemotherapy present a hypercoagulable state.•Thrombin generation showed changes in patients using doxorubicin according to cardiotoxicity.•Thrombin generation parameters may be useful in monitoring hemostasis in these patients.

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Veröffentlicht in:Thrombosis research 2022-03, Vol.211, p.56-59
Hauptverfasser: Pestana, Rodrigo M.C., Duarte, Rita C.F., Alves, Michelle T., de Oliveira, Angélica N., Oliveira, Heloísa H.M., Soares, Cintia E., de P. Sabino, Adriano, Silva, Luciana M., das Graças Carvalho, Maria, Simões, Ricardo, Gomes, Karina B.
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container_end_page 59
container_issue
container_start_page 56
container_title Thrombosis research
container_volume 211
creator Pestana, Rodrigo M.C.
Duarte, Rita C.F.
Alves, Michelle T.
de Oliveira, Angélica N.
Oliveira, Heloísa H.M.
Soares, Cintia E.
de P. Sabino, Adriano
Silva, Luciana M.
das Graças Carvalho, Maria
Simões, Ricardo
Gomes, Karina B.
description •Patients with breast cancer and doxorubicin-based chemotherapy present a hypercoagulable state.•Thrombin generation showed changes in patients using doxorubicin according to cardiotoxicity.•Thrombin generation parameters may be useful in monitoring hemostasis in these patients.
doi_str_mv 10.1016/j.thromres.2022.01.009
format Article
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Antineoplastic Combined Chemotherapy Protocols
Breast cancer
Breast Neoplasms - drug therapy
Cardiotoxicity
Cardiotoxicity - etiology
Doxorubicin
Doxorubicin - adverse effects
Female
Follow-Up Studies
Hemostasis
Hemostatics - therapeutic use
Humans
Thrombin generation
title Hemostatic status in women with breast cancer and cardiotoxicity associated to doxorubicin-based chemotherapy – A one-year follow-up study
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