FOXM1 mediates GDF-15 dependent stemness and intrinsic drug resistance in breast cancer

FOXM1 mediates GDF-15 dependent stemness and intrinsic drug resistance in breast cancer

Background Stemness, a key component of breast cancer (BC) heterogeneity, is responsible for chemoresistance. Growth differentiation factor-15 (GDF-15) induces drug resistance and stemness in BC cells. In this study, the expressions and interactions of GDF-15, FOXM1, and stemness (OCT4 and SOX2), an...

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Veröffentlicht in:Molecular biology reports 2022-04, Vol.49 (4), p.2877-2888
Hauptverfasser: Modi, Anupama, Purohit, Purvi, Roy, Dipayan, Vishnoi, Jeewan Ram, Pareek, Puneet, Elhence, Poonam, Singh, Priyanka, Sharma, Shailja, Sharma, Praveen, Misra, Sanjeev
Format: Artikel
Sprache:eng
Schlagworte:
AKT protein
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Line, Tumor
Chemoresistance
Drug resistance
Drug Resistance, Neoplasm
Female
Forkhead Box Protein M1 - genetics
Growth Differentiation Factor 15 - metabolism
Growth Differentiation Factor 15 - therapeutic use
Histology
Humans
Life Sciences
Morphology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Oct-4 protein
Original Article
Patients
Polymerase chain reaction
Signal transduction
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Zusammenfassung:Background Stemness, a key component of breast cancer (BC) heterogeneity, is responsible for chemoresistance. Growth differentiation factor-15 (GDF-15) induces drug resistance and stemness in BC cells. In this study, the expressions and interactions of GDF-15, FOXM1, and stemness (OCT4 and SOX2), and drug resistance (ABCC5) markers were evaluated in BC. Methods and results 40 diagnosed BC patients and 40 healthy controls were included in this study. Serum GDF-15 was significantly raised ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-07102-5