Do Vitamin D receptor gene polymorphisms affect bone mass density in men?: A meta-analysis of observational studies

The signs of aging in humans can often be detected through a decrease in bone mass density (BMD). The decrease in BMD as a risk of osteoporosis is often only seen in women, but not in men, even though men also have a risk of osteoporosis which can affect their well-being. We conducted study searches...

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Veröffentlicht in:Ageing research reviews 2022-03, Vol.75, p.101571-101571, Article 101571
Hauptverfasser: Pakpahan, Cennikon, Wungu, Citrawati Dyah Kencono, Agustinus, Agustinus, Darmadi, Darmadi
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Sprache:eng
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Zusammenfassung:The signs of aging in humans can often be detected through a decrease in bone mass density (BMD). The decrease in BMD as a risk of osteoporosis is often only seen in women, but not in men, even though men also have a risk of osteoporosis which can affect their well-being. We conducted study searches through databases such as PubMed, EBSCO, ProQuest, Willey Online, Science Direct, and SAGE. We performed analysis on four types of Vitamin D receptor polymorphisms: BsmI, ApaI, FokI, and TaqI from 14 potential studies involving men. We found that several genetic analysis models of BsmI and FokI significantly affected BMD in men: BB vs bb in whole body BMD (SMD = 0.43, 95% CI = [0.12–0.75], p = 0.0008, BB vs Bb in whole body BMD (SMD = −1.38, 95% CI = [−1.87 to 0.88], p 
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2022.101571