Treatment outcomes with purine nucleoside analog alone or with rituximab for hairy cell leukemia at first relapse
Introduction Frontline treatment of hairy cell leukemia (HCL) with a single course of the purine nucleoside analog (PNA) produces a high rate of complete remission (CR) with prolonged durations. At the time of relapse, although treatment guidelines recommend re‐treatment with a PNA alone or in combi...
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Veröffentlicht in: | European journal of haematology 2022-05, Vol.108 (5), p.379-382 |
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Sprache: | eng |
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Zusammenfassung: | Introduction
Frontline treatment of hairy cell leukemia (HCL) with a single course of the purine nucleoside analog (PNA) produces a high rate of complete remission (CR) with prolonged durations. At the time of relapse, although treatment guidelines recommend re‐treatment with a PNA alone or in combination with rituximab (R), practice patterns vary and data supporting each approach are limited.
Methods
We conducted a multisite outcomes analysis of patients treated for HCL between 1995 and 2018 at six US medical centers. All patients were treated with frontline PNA and subsequently required treatment with a PNA alone (PNA) or with R (+R).
Results
Of the 88 patients analyzed, 56 (63.6%) received second‐line PNA and 22 (36.4%) received a PNA + R. Baseline characteristics of both groups were similar. There was no difference in median PFS [67 months (95% CI 43.8 non‐reached (NR)) vs. 65 months (95% CI 60‐NR)] or 5‐year OS [98% (95% CI 0.94–1) vs. 94% (95% CI 0.83–1), p = .104] in the PNA versus PNA + R cohorts, respectively.
Conclusion
To our knowledge, this is the largest study evaluating the role of R in treatment of relapsed HCL and suggests that there is no advantage to the addition of R to PNA therapy at the time of first re‐treatment. |
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ISSN: | 0902-4441 1600-0609 |
DOI: | 10.1111/ejh.13744 |