Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans

Lentinan, extracted from Lentinus edodes, exhibits bioactive properties in vitro; however, little is known about the antioxidant potential in vivo. In this study, the effects of lentinan at 0.05, 0.25 and 1.25 mg/mL on the lifespan, locomotion, reproductive capacity, and oxidative stress resistance...

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Veröffentlicht in:	International journal of biological macromolecules 2022-03, Vol.202, p.286-295
Hauptverfasser:	Liu, Huimin, Wang, Ying, Zhang, Weiping, Sun, Weichao, Ji, Xiaoxue, Zhang, Shouan, Qiao, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Insulin/IGF-1 signaling Lentinan Lentinan - pharmacology Longevity Oxidative Stress Reactive Oxygen Species - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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Zusammenfassung:	Lentinan, extracted from Lentinus edodes, exhibits bioactive properties in vitro; however, little is known about the antioxidant potential in vivo. In this study, the effects of lentinan at 0.05, 0.25 and 1.25 mg/mL on the lifespan, locomotion, reproductive capacity, and oxidative stress resistance in Caenorhabditis elegans were determined. Compared to the untreated control, lentinan at 0.05, 0.25 and 1.25 mg/mL significantly prolonged the lifespan by 17.6%, 35.3% and 25.3% (p
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2022.01.071