The bidirectional relationship between metabolic syndrome and hyperuricemia in China: A longitudinal study from CHARLS

Objective It has been reported that metabolic syndrome (MetS) has been associated with hyperuricemia. However, current findings have been inconclusive regarding the direction of this association. The objective of this study was to clarify the possible directional relationship between hyperuricemia and MetS. Design This study used two waves of data from the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015 ( N = 6,253, aged ≥40 years). Logistic regression and cross-lagged panel design were performed to evaluate the bidirectional association between uric acid with MetS. MetS score is defined as the number of MetS components present. Results New-onset hyperuricemia and MetS were observed in a four-year follow-up study among 719 and 625 participants, respectively. A positive association was observed in the adjusted logistical regression model between baseline MetS score and new-onset hyperuricemia ( P for trend