Low-density lipoprotein cholesterol levels and adverse clinical outcomes in chronic kidney disease: Results from the KNOW-CKD

The optimal low-density lipoprotein cholesterol (LDL-C) level to prevent cardiovascular disease in chronic kidney disease (CKD) patients remains unknown. This study aimed to explore the association of LDL-C levels with adverse cardiovascular and kidney outcomes in Korean CKD patients and determine t...

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Veröffentlicht in:	Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2022-02, Vol.32 (2), p.410-419
Hauptverfasser:	Lee, Changhyun, Park, Jung Tak, Chang, Tae-Ik, Kang, Ea Wha, Nam, Ki Heon, Joo, Young Su, Sung, Su-Ah, Kim, Yeong Hoon, Chae, Dong-Wan, Park, Su Kyung, Ahn, Curie, Oh, Kook-Hwan, Yoo, Tae-Hyun, Kang, Shin-Wook, Han, Seung Hyeok
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Cardiovascular event Cholesterol, LDL Chronic kidney disease Cohort Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Kidney outcome Low-density lipoprotein cholesterol Mortality Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - therapy
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Beschreibung
Zusammenfassung:	The optimal low-density lipoprotein cholesterol (LDL-C) level to prevent cardiovascular disease in chronic kidney disease (CKD) patients remains unknown. This study aimed to explore the association of LDL-C levels with adverse cardiovascular and kidney outcomes in Korean CKD patients and determine the validity of “the lower, the better” strategy for statin intake. A total of 1886 patients from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD) were included. Patients were classified into four LDL-C categories:
ISSN:	0939-4753 1590-3729
DOI:	10.1016/j.numecd.2021.09.037