Pd-Catalyzed Regioselective Branched Hydrocarboxylation of Terminal Olefins with Formic Acid

Pd-Catalyzed Regioselective Branched Hydrocarboxylation of Terminal Olefins with Formic Acid

A regioselective Pd-catalyzed hydrocarboxylation of terminal olefins with HCOOH is described. A wide variety of branched carboxylic acids can readily be obtained with high regioselectivities under mild reaction conditions. The reaction is operationally simple and requires no handling of toxic CO. Th...

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Veröffentlicht in:Organic letters 2022-01, Vol.24 (3), p.886-891
Hauptverfasser: Ren, Wenlong, Wang, Mingzhou, Guo, Jianqiong, Zhou, Jintao, Chu, Jianxiao, Shi, Yuan, Shi, Yian
Format: Artikel
Sprache:eng
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Zusammenfassung:A regioselective Pd-catalyzed hydrocarboxylation of terminal olefins with HCOOH is described. A wide variety of branched carboxylic acids can readily be obtained with high regioselectivities under mild reaction conditions. The reaction is operationally simple and requires no handling of toxic CO. The ligand and LiCl are important factors for reaction reactivity and selectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c04231