The rs6942067 genotype is associated with a worse overall survival in young or non-smoking HPV-negative patients with positive nodal status in head and neck squamous cell carcinoma

•HNSCC patients with rs6942067 GG genotype have a worse overall survival.•HNSCC patients with rs6942067 GG genotype have higher occurrence of N+ tumors.•Occurrency of rs6940267 GG is higher for N+ patients young or without risk factors.•Patients with rs6942067 have higher risk of HNSCC than the gene...

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Veröffentlicht in:	Oral oncology 2022-02, Vol.125, p.105696-105696, Article 105696
Hauptverfasser:	Cardin, Guillaume B., Bernard, Monique, Bourbonnais, Jessica, Bahig, Houda, Nguyen-Tan, Phuc Félix, Filion, Edith, Soulieres, Denis, Gologan, Olguta, Ayad, Tareck, Guertin, Louis, Bissada, Eric, Rodier, Francis, Christopoulos, Apostolos
Format:	Artikel
Sprache:	eng
Schlagworte:	Genotype Head and Neck Neoplasms - genetics Humans Oropharyngeal Neoplasms - pathology Papillomavirus Infections - complications Papillomavirus Infections - genetics Squamous Cell Carcinoma of Head and Neck - genetics
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Zusammenfassung:	•HNSCC patients with rs6942067 GG genotype have a worse overall survival.•HNSCC patients with rs6942067 GG genotype have higher occurrence of N+ tumors.•Occurrency of rs6940267 GG is higher for N+ patients young or without risk factors.•Patients with rs6942067 have higher risk of HNSCC than the general population.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2021.105696