ProSynAR: a reference aware read merger

Abstract Motivation Read-merging algorithms that look solely at the reads can misalign and mis-merge the reads (especially near repetitive sequences). Results The C++ program ProSynAR has been written to take the reads’ position in the reference into account when performing (and deciding whether to...

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Veröffentlicht in:	Bioinformatics 2022-03, Vol.38 (7), p.2052-2053
Hauptverfasser:	Crysup, Benjamin, Budowle, Bruce, Woerner, August E
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms High-Throughput Nucleotide Sequencing Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA Software
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Beschreibung
Zusammenfassung:	Abstract Motivation Read-merging algorithms that look solely at the reads can misalign and mis-merge the reads (especially near repetitive sequences). Results The C++ program ProSynAR has been written to take the reads’ position in the reference into account when performing (and deciding whether to perform) a merge. Availability *Nix users can retrieve the source from GitHub (https://github.com/Benjamin-Crysup/prosynar). Windows binary available at https://github.com/Benjamin-Crysup/prosynar/releases/download/1.0/prosynar.zip. Supplementary information Supplementary data are available at Bioinformatics online.
ISSN:	1367-4803 1460-2059 1367-4811
DOI:	10.1093/bioinformatics/btac022