Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study
What is known and objective In our preliminary study, there were large individual variations at sedation levels during propofol target‐controlled infusion (TCI). The present study aimed to assess the effects of body mass index (BMI) on the pharmacodynamic index of propofol TCI. Methods This prospect...
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| Veröffentlicht in: | Journal of clinical pharmacy and therapeutics 2022-05, Vol.47 (5), p.662-667 |
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| creator | Wu, Zijuan Gong, Jinhong He, Xiaomei Wu, Zhouquan Shen, Jingjing Shang, Jingjing |
| description | What is known and objective
In our preliminary study, there were large individual variations at sedation levels during propofol target‐controlled infusion (TCI). The present study aimed to assess the effects of body mass index (BMI) on the pharmacodynamic index of propofol TCI.
Methods
This prospective, non‐randomized controlled trial evaluated 175 female patients undergoing breast lumpectomy. Anesthesia was induced with propofol using the TCI system embedded Schnider model. The effect compartment concentration was set to 3 μg/ml, and the start time of infusion was recorded. When the target concentration reached 3 μg/ml, the patient could not be awakened (Ramsay sedation score ≥4), and when the Bispectral Index (BIS) was |
| doi_str_mv | 10.1111/jcpt.13594 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2619217108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2619217108</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4234-3d55e8435ffbf423b0c553fe5d4e14eb2dfe06931ecb4a363d3c76465733c5393</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EYoYpGx4ARWJTIWVqxz9J2JURP0UjtYt2HTn2dckosYOdUMIK3qDP2Cep02krxKLe2Lr3O0f3-iD0huA1iedop_phTSgv2TO0JFTwNMsJfo6WOBNlyvIsX6BXIewwxiLP6Eu0oByTQrBiif5-dHpKOhlC0lgNvxJpddJ_l76TKnas7BoVEmeSQfpLGG7-XCtnB-_aFnRUmDE0zs793rveGdd-SI7nd-hBDc1PSKyzUeSjreua31H0jz4Mo54O0Asj2wCv7-8Vuvj86XzzNd2efjnZHG9TxTLKUqo5h4JRbkxtYqXGinNqgGsGhEGdaQNYlJSAqpmkgmqqcsEEzylVnJZ0hQ73vnG6HyOEoeqaoKBtpQU3hioTpMxI_Lgiou_-Q3du9DZOFykhGC7ygkTq_Z5Scd3gwVS9bzrpp4rgag6mmoOp7oKJ8Nt7y7HuQD-iD0lEgOyBq6aF6Qmr6tvm7Hxvegv4fZys</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2666408781</pqid></control><display><type>article</type><title>Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wu, Zijuan ; Gong, Jinhong ; He, Xiaomei ; Wu, Zhouquan ; Shen, Jingjing ; Shang, Jingjing</creator><creatorcontrib>Wu, Zijuan ; Gong, Jinhong ; He, Xiaomei ; Wu, Zhouquan ; Shen, Jingjing ; Shang, Jingjing</creatorcontrib><description>What is known and objective
In our preliminary study, there were large individual variations at sedation levels during propofol target‐controlled infusion (TCI). The present study aimed to assess the effects of body mass index (BMI) on the pharmacodynamic index of propofol TCI.
Methods
This prospective, non‐randomized controlled trial evaluated 175 female patients undergoing breast lumpectomy. Anesthesia was induced with propofol using the TCI system embedded Schnider model. The effect compartment concentration was set to 3 μg/ml, and the start time of infusion was recorded. When the target concentration reached 3 μg/ml, the patient could not be awakened (Ramsay sedation score ≥4), and when the Bispectral Index (BIS) was <60, the infusion was discontinued, and the time point was recorded. The observation end‐point was set at the Observer's Assessment of Alertness/Sedation (OAA/S) score of <4. The correlation between the BMI and the pharmacodynamic index of propofol was evaluated.
Results and discussion
Propofol induction time was significantly correlated with the BMI (p < 0.001). The induction time of the underweight subjects was 10.14 ± 2.19 min, which was remarkably higher than that of normal weight (6.48 ± 3.44 min) and overweight (4.75 ± 2.53 min) individuals (p < 0.001). There were still significant differences after multivariable‐adjusted regressions (p < 0.001). There were no significant differences in recovery time and sedative effect indicators, such as Ramsay score, BIS value, and effect compartment concentration, between the three groups (p > 0.05 for all).
What is new and conclusion
These results suggest that the BMI is one of the critical factors affecting the pharmacodynamic index of propofol TCI, and the induction time decreased progressively with increasing BMI. The Schnider model might underpredict doses of propofol for underweight individuals.
BMI is one of the critical factors affecting the pharmacodynamic index of propofol target‐controlled infusion, and the induction time decreased progressively with increasing BMI. The Schnider model might underpredict doses of propofol for underweight individuals.</description><identifier>ISSN: 0269-4727</identifier><identifier>EISSN: 1365-2710</identifier><identifier>DOI: 10.1111/jcpt.13594</identifier><identifier>PMID: 35018648</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Anesthesia ; Anesthetics, Intravenous - pharmacology ; Body Mass Index ; Body weight ; Breast ; Female ; Humans ; Lumpectomy ; Overweight ; Pharmacodynamics ; Propofol ; Propofol - pharmacology ; Prospective Studies ; Schnider model ; target controlled infusion ; Thinness ; Underweight</subject><ispartof>Journal of clinical pharmacy and therapeutics, 2022-05, Vol.47 (5), p.662-667</ispartof><rights>2022 John Wiley & Sons Ltd</rights><rights>2022 John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4234-3d55e8435ffbf423b0c553fe5d4e14eb2dfe06931ecb4a363d3c76465733c5393</citedby><cites>FETCH-LOGICAL-c4234-3d55e8435ffbf423b0c553fe5d4e14eb2dfe06931ecb4a363d3c76465733c5393</cites><orcidid>0000-0002-5267-933X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpt.13594$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpt.13594$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35018648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Zijuan</creatorcontrib><creatorcontrib>Gong, Jinhong</creatorcontrib><creatorcontrib>He, Xiaomei</creatorcontrib><creatorcontrib>Wu, Zhouquan</creatorcontrib><creatorcontrib>Shen, Jingjing</creatorcontrib><creatorcontrib>Shang, Jingjing</creatorcontrib><title>Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study</title><title>Journal of clinical pharmacy and therapeutics</title><addtitle>J Clin Pharm Ther</addtitle><description>What is known and objective
In our preliminary study, there were large individual variations at sedation levels during propofol target‐controlled infusion (TCI). The present study aimed to assess the effects of body mass index (BMI) on the pharmacodynamic index of propofol TCI.
Methods
This prospective, non‐randomized controlled trial evaluated 175 female patients undergoing breast lumpectomy. Anesthesia was induced with propofol using the TCI system embedded Schnider model. The effect compartment concentration was set to 3 μg/ml, and the start time of infusion was recorded. When the target concentration reached 3 μg/ml, the patient could not be awakened (Ramsay sedation score ≥4), and when the Bispectral Index (BIS) was <60, the infusion was discontinued, and the time point was recorded. The observation end‐point was set at the Observer's Assessment of Alertness/Sedation (OAA/S) score of <4. The correlation between the BMI and the pharmacodynamic index of propofol was evaluated.
Results and discussion
Propofol induction time was significantly correlated with the BMI (p < 0.001). The induction time of the underweight subjects was 10.14 ± 2.19 min, which was remarkably higher than that of normal weight (6.48 ± 3.44 min) and overweight (4.75 ± 2.53 min) individuals (p < 0.001). There were still significant differences after multivariable‐adjusted regressions (p < 0.001). There were no significant differences in recovery time and sedative effect indicators, such as Ramsay score, BIS value, and effect compartment concentration, between the three groups (p > 0.05 for all).
What is new and conclusion
These results suggest that the BMI is one of the critical factors affecting the pharmacodynamic index of propofol TCI, and the induction time decreased progressively with increasing BMI. The Schnider model might underpredict doses of propofol for underweight individuals.
BMI is one of the critical factors affecting the pharmacodynamic index of propofol target‐controlled infusion, and the induction time decreased progressively with increasing BMI. The Schnider model might underpredict doses of propofol for underweight individuals.</description><subject>Anesthesia</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Breast</subject><subject>Female</subject><subject>Humans</subject><subject>Lumpectomy</subject><subject>Overweight</subject><subject>Pharmacodynamics</subject><subject>Propofol</subject><subject>Propofol - pharmacology</subject><subject>Prospective Studies</subject><subject>Schnider model</subject><subject>target controlled infusion</subject><subject>Thinness</subject><subject>Underweight</subject><issn>0269-4727</issn><issn>1365-2710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EYoYpGx4ARWJTIWVqxz9J2JURP0UjtYt2HTn2dckosYOdUMIK3qDP2Cep02krxKLe2Lr3O0f3-iD0huA1iedop_phTSgv2TO0JFTwNMsJfo6WOBNlyvIsX6BXIewwxiLP6Eu0oByTQrBiif5-dHpKOhlC0lgNvxJpddJ_l76TKnas7BoVEmeSQfpLGG7-XCtnB-_aFnRUmDE0zs793rveGdd-SI7nd-hBDc1PSKyzUeSjreua31H0jz4Mo54O0Asj2wCv7-8Vuvj86XzzNd2efjnZHG9TxTLKUqo5h4JRbkxtYqXGinNqgGsGhEGdaQNYlJSAqpmkgmqqcsEEzylVnJZ0hQ73vnG6HyOEoeqaoKBtpQU3hioTpMxI_Lgiou_-Q3du9DZOFykhGC7ygkTq_Z5Scd3gwVS9bzrpp4rgag6mmoOp7oKJ8Nt7y7HuQD-iD0lEgOyBq6aF6Qmr6tvm7Hxvegv4fZys</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Wu, Zijuan</creator><creator>Gong, Jinhong</creator><creator>He, Xiaomei</creator><creator>Wu, Zhouquan</creator><creator>Shen, Jingjing</creator><creator>Shang, Jingjing</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5267-933X</orcidid></search><sort><creationdate>202205</creationdate><title>Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study</title><author>Wu, Zijuan ; Gong, Jinhong ; He, Xiaomei ; Wu, Zhouquan ; Shen, Jingjing ; Shang, Jingjing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4234-3d55e8435ffbf423b0c553fe5d4e14eb2dfe06931ecb4a363d3c76465733c5393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anesthesia</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Breast</topic><topic>Female</topic><topic>Humans</topic><topic>Lumpectomy</topic><topic>Overweight</topic><topic>Pharmacodynamics</topic><topic>Propofol</topic><topic>Propofol - pharmacology</topic><topic>Prospective Studies</topic><topic>Schnider model</topic><topic>target controlled infusion</topic><topic>Thinness</topic><topic>Underweight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Zijuan</creatorcontrib><creatorcontrib>Gong, Jinhong</creatorcontrib><creatorcontrib>He, Xiaomei</creatorcontrib><creatorcontrib>Wu, Zhouquan</creatorcontrib><creatorcontrib>Shen, Jingjing</creatorcontrib><creatorcontrib>Shang, Jingjing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacy and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Zijuan</au><au>Gong, Jinhong</au><au>He, Xiaomei</au><au>Wu, Zhouquan</au><au>Shen, Jingjing</au><au>Shang, Jingjing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study</atitle><jtitle>Journal of clinical pharmacy and therapeutics</jtitle><addtitle>J Clin Pharm Ther</addtitle><date>2022-05</date><risdate>2022</risdate><volume>47</volume><issue>5</issue><spage>662</spage><epage>667</epage><pages>662-667</pages><issn>0269-4727</issn><eissn>1365-2710</eissn><abstract>What is known and objective
In our preliminary study, there were large individual variations at sedation levels during propofol target‐controlled infusion (TCI). The present study aimed to assess the effects of body mass index (BMI) on the pharmacodynamic index of propofol TCI.
Methods
This prospective, non‐randomized controlled trial evaluated 175 female patients undergoing breast lumpectomy. Anesthesia was induced with propofol using the TCI system embedded Schnider model. The effect compartment concentration was set to 3 μg/ml, and the start time of infusion was recorded. When the target concentration reached 3 μg/ml, the patient could not be awakened (Ramsay sedation score ≥4), and when the Bispectral Index (BIS) was <60, the infusion was discontinued, and the time point was recorded. The observation end‐point was set at the Observer's Assessment of Alertness/Sedation (OAA/S) score of <4. The correlation between the BMI and the pharmacodynamic index of propofol was evaluated.
Results and discussion
Propofol induction time was significantly correlated with the BMI (p < 0.001). The induction time of the underweight subjects was 10.14 ± 2.19 min, which was remarkably higher than that of normal weight (6.48 ± 3.44 min) and overweight (4.75 ± 2.53 min) individuals (p < 0.001). There were still significant differences after multivariable‐adjusted regressions (p < 0.001). There were no significant differences in recovery time and sedative effect indicators, such as Ramsay score, BIS value, and effect compartment concentration, between the three groups (p > 0.05 for all).
What is new and conclusion
These results suggest that the BMI is one of the critical factors affecting the pharmacodynamic index of propofol TCI, and the induction time decreased progressively with increasing BMI. The Schnider model might underpredict doses of propofol for underweight individuals.
BMI is one of the critical factors affecting the pharmacodynamic index of propofol target‐controlled infusion, and the induction time decreased progressively with increasing BMI. The Schnider model might underpredict doses of propofol for underweight individuals.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>35018648</pmid><doi>10.1111/jcpt.13594</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5267-933X</orcidid></addata></record> |
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| ispartof | Journal of clinical pharmacy and therapeutics, 2022-05, Vol.47 (5), p.662-667 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anesthesia Anesthetics, Intravenous - pharmacology Body Mass Index Body weight Breast Female Humans Lumpectomy Overweight Pharmacodynamics Propofol Propofol - pharmacology Prospective Studies Schnider model target controlled infusion Thinness Underweight |
| title | Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study |
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