Body mass index and pharmacodynamics of target‐controlled infusion of propofol: A prospective non‐randomized controlled study

What is known and objective In our preliminary study, there were large individual variations at sedation levels during propofol target‐controlled infusion (TCI). The present study aimed to assess the effects of body mass index (BMI) on the pharmacodynamic index of propofol TCI. Methods This prospective, non‐randomized controlled trial evaluated 175 female patients undergoing breast lumpectomy. Anesthesia was induced with propofol using the TCI system embedded Schnider model. The effect compartment concentration was set to 3 μg/ml, and the start time of infusion was recorded. When the target concentration reached 3 μg/ml, the patient could not be awakened (Ramsay sedation score ≥4), and when the Bispectral Index (BIS) was