Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction

We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, A...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2022, Vol.172 (3), p.314-317
Hauptverfasser:	Spasov, A. A., Kucheryavenko, A. F., Khaliullin, F. A., Gurova, N. A., Sirotenko, V. S., Samorodov, A. V., Gaidukova, K. A., Pavlov, V. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiplatelet therapy Biomedical and Life Sciences Biomedicine Blood clot Cardiac glycosides Cardiotonic agents Carotid artery Cell Biology Comorbidity Complications and side effects Eptifibatide Ferric chloride Fibrin Fibrinogen Fibrinolytic Agents - pharmacology Fibrinolytic Agents - therapeutic use Heart attack Heart attacks Heterocyclic compounds Internal Medicine Isoproterenol Isoproterenol - adverse effects Laboratory Medicine Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - drug therapy Pathology Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - adverse effects Rats Thrombosis Thrombosis - chemically induced Thrombosis - drug therapy Tirofiban Tyrosine
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Zusammenfassung:	We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, Angipur administered intravenously was 1.2 times less effective, in terms of ED 50 , than the well-known inhibitor of GPIIb/IIIa platelet receptors tirofiban. However, under conditions of non-coronary myocardial infarction, Angipur significantly prolonged the time of thrombus formation and exhibited 1.4-fold higher activity than the reference drug tirofiban.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-022-05383-9