Evaluating the Impact of Cardiopulmonary Bypass Priming Fluids on Bleeding After Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis

•Pediatric cardiac surgery on bypass warrants age/weight adjusted blood management.•Pediatric data investigating bypass priming fluids is sparse and heterogenous.•Most frequently assessed is the addition of FFP to the prime.•Targeted fibrinogen addition to the prime should be investigated in future studies.•Questions for future research also consider the optimal colloid oncotic pressure. Cardiopulmonary bypass (CPB) predisposes young children to coagulopathy. The authors evaluated possible effects of CPB priming fluids on perioperative bleeding in pediatric cardiac surgery. Meta-analysis and systematic review of previously published studies. Each study was conducted in a surgical center or intensive care unit. Studies investigating patients