Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

Quinoxalinones are a class of heterocyclic compounds which attract extensive attention owing to their potential in the field of organic synthesis and medicinal chemistry. During the past few decades, many new synthetic strategies toward the functionalization of quinoxalinone based scaffolds have been witnessed. Regrettably, there are only a few reports on the pharmacological activities of quinoxalinone scaffolds from a medicinal chemistry perspective. Therefore, herein we intend to outline the applications of multifunctional quinoxalinones as privileged structures possessing various biological activities, including anticancer, neuroprotective, antibacterial, antiviral, antiparasitic, anti-inflammatory, antiallergic, anti-cardiovascular, anti-diabetes, antioxidation, etc. We hope that this review will facilitate the development of quinoxalinone derivatives in medicinal chemistry. [Display omitted] •Quinoxalinone is a promising framework for functionalization and structural modification.•The privileged structures of multifunctional quinoxalinones possess various biological activities.•Quinoxalinone derivatives provide potential lead compounds for drug discovery and development.•The quinoxalinone derivatives and their pharmacological activities were reviewed.