Mixtures modeling identifies vitamin B1 and B3 intakes associated with depression

•Mixture intakes of B vitamins through an ordinary diet is promising therapy for depression.•The joint effect of mixed vitamin intake on depression was assessed.•The results of four models were combined to come up with a reliable conclusion.•The cutoff levels for B vitamin intake levels related to depression were reported. We aim to identify the association between a mixture of vitamin B1, B2, and B3 intakes and depression. Daily intake of vitamins was measured by a one-day 24 h recall. Multivariate logistic regression, weighted quantile sum (WQS), quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) were used. Of 9,848 adults included in the final analysis, 4.38% had depression. In the logistic regression model, daily vitamin B1 and B3 intakes were associated with depression, and significant trends were observed for these vitamin intake tertiles (p