Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of N -(2-iodo-aryl) acrylamide

Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of N -(2-iodo-aryl) acrylamide

A Ni/( , )-BDPP-catalyzed intramolecular Heck cyclization of -(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-01, Vol.58 (8), p.1135-1138
Hauptverfasser: Wang, Guangzhu, Shen, Chaoren, Ren, Xinyi, Dong, Kaiwu
Format: Artikel
Sprache:eng
Schlagworte:
Acrylamide
Aromatic compounds
Enantiomers
Reagents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A Ni/( , )-BDPP-catalyzed intramolecular Heck cyclization of -(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc04996h