Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators

NMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit c...

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Veröffentlicht in:	Cellular and molecular neurobiology 2023-01, Vol.43 (1), p.139-153
Hauptverfasser:	Niu, Menghan, Yang, Xin, Li, Yuanyuan, Sun, Yanping, Wang, Long, Ha, Jing, Xie, Yinghua, Gao, Zibin, Tian, Changzheng, Wang, Le, Sun, Yongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Excitatory Amino Acid Antagonists - pharmacology Glutamic acid receptors (ionotropic) N-Methyl-D-aspartic acid receptors Neurobiology Neurological diseases Neuronal Plasticity Neurosciences Receptor mechanisms Receptors, N-Methyl-D-Aspartate - metabolism Review Paper Subunit structure Synaptic plasticity
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Zusammenfassung:	NMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing NMDA receptors as well as selective GluN2A regulators were described to further understand this type of NMDA receptors.
ISSN:	0272-4340 1573-6830
DOI:	10.1007/s10571-021-01185-1