Infiltration pattern predicts metastasis and progression better than the T-stage and grade in pancreatic neuroendocrine tumors: a proposal for a novel infiltration-based morphologic grading

Infiltration pattern predicts metastasis and progression better than the T-stage and grade in pancreatic neuroendocrine tumors: a proposal for a novel infiltration-based morphologic grading

The advancing edge profile is a powerful determinant of tumor behavior in many organs. In this study, a grading system assessing the tumor-host interface was developed and tested in 181 pancreatic neuroendocrine tumors (PanNETs), 63 of which were 

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Veröffentlicht in:Modern pathology 2022-06, Vol.35 (6), p.777-785
Hauptverfasser: Taskin, Orhun Cig, Reid, Michelle D., Bagci, Pelin, Balci, Serdar, Armutlu, Ayse, Demirtas, Deniz, Pehlivanoglu, Burcin, Saka, Burcu, Memis, Bahar, Bozkurtlar, Emine, Leblebici, Can Berk, Birceanu, Adelina, Xue, Yue, Erkan, Mert, Kapran, Yersu, Baygul, Arzu, Sokmensuer, Cenk, Scarpa, Aldo, Luchini, Claudio, Basturk, Olca, Adsay, Volkan
Format: Artikel
Sprache:eng
Schlagworte:
631/67/1459/1963
631/67/1504/1713
Humans
Infiltration
Invasiveness
Laboratory Medicine
Medicine
Medicine & Public Health
Metastases
Metastasis
Multivariate analysis
Neoplasm Grading
Neuroendocrine tumors
Neuroendocrine Tumors - pathology
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - pathology
Pathology
Prognosis
Statistical analysis
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Zusammenfassung:The advancing edge profile is a powerful determinant of tumor behavior in many organs. In this study, a grading system assessing the tumor-host interface was developed and tested in 181 pancreatic neuroendocrine tumors (PanNETs), 63 of which were 
ISSN:0893-3952
1530-0285
DOI:10.1038/s41379-021-00995-4