Autobiographical Memory Impairments as a Transdiagnostic Feature of Mental Illness: A Meta-Analytic Review of Investigations Into Autobiographical Memory Specificity and Overgenerality Among People With Psychiatric Diagnoses

Decades of research has examined the difficulty that people with psychiatric diagnoses have in recalling specific autobiographical memories of events that lasted less than a day. Instead, they seem to retrieve general events that have occurred many times or which occurred over longer periods of time, termed overgeneral memory. We present the first transdiagnostic meta-analysis of memory specificity/overgenerality and the first meta-regression of proposed causal mechanisms. A keyword search of Embase, PsycARTICLES, and PsycINFO databases yielded 74 studies that compared people with and without psychiatric diagnoses on the retrieval of specific (k = 85) or general memories (k = 56). The majority of studies included participants with Major Depressive Disorder (∼49%), Schizophrenia (∼19%), and Posttraumatic Stress Disorder (∼17%) with few studies involving other groups of participants, for example, Anxiety Disorders (∼5%). Multilevel meta-analysis confirmed that people with psychiatric diagnoses typically recall fewer specific, g = −0.864, 95% CI [−1.030, −0.698], and more general, g = 712, 95% CI [0.524, 0.900], memories than diagnoses-free people. The size of these effects did not differ between diagnostic groups. There were no consistent moderators of effect size heterogeneity; effect sizes were not explained by methodological factors such as cue valence or demographic variables such as participants' age or between-group differences in process variables (e.g., rumination). Deficits in autobiographical memory retrieval may be a transdiagnostic factor, but further research in underrepresented diagnostic groups, and with novel experimental manipulations of encoding and retrieval processes, is warranted before full transdiagnosticity and the processes underlying reduced specificity/overgenerality can be established. Public Significance Statement The data presented here show that people with a range of psychiatric diagnoses experience difficulty retrieving memories of specific autobiographical events from their past. Instead, people with diagnoses tend to retrieve memories of general events that have occurred on multiple occasions or which occur over an extended period of time. These findings indicate a specific cognitive target for intervention in psychiatric problems, especially given that existing treatments do not typically help people in this way. These findings also contribute to a growing body of literature that indicates similarities in cognitive deficit