Is downregulation of liver kinase B1 the major factor driving epithelial‐to‐mesenchymal transition?

Is downregulation of liver kinase B1 the major factor driving epithelial‐to‐mesenchymal transition?

Liver kinase B1 regulates cell growth, polarity, metabolism, and autophagy via phosphorylation of adenosine monophosphate‐activated protein kinase, and its downregulation may stimulate epithelial‐to‐mesenchymal transition in chronic lung allograft dysfunction. (See Rahman et al. page 843)

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Bibliographische Detailangaben
Veröffentlicht in:American journal of transplantation 2022-03, Vol.22 (3), p.689-690
Hauptverfasser: Bos, Saskia, Fisher, Andrew J.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine kinase
AMP
Autophagy
Down-Regulation
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Hepatocytes
Kinases
Liver
Lung transplantation
Mesenchyme
Phosphorylation
Polarity
Protein kinase
Xenografts
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Beschreibung
Zusammenfassung:Liver kinase B1 regulates cell growth, polarity, metabolism, and autophagy via phosphorylation of adenosine monophosphate‐activated protein kinase, and its downregulation may stimulate epithelial‐to‐mesenchymal transition in chronic lung allograft dysfunction. (See Rahman et al. page 843)
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.16941