H3.3 safeguards haematopoietic ERV-quilibrium
Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterati...
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| Veröffentlicht in: | Nature cell biology 2022-01, Vol.24 (1), p.7-9 |
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| container_title | Nature cell biology |
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| creator | Cipta, Nadia Omega Chen, Ying Loh, Yuin-Han |
| description | Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterations. |
| doi_str_mv | 10.1038/s41556-021-00758-y |
| format | Article |
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| subjects | 631/337/176 631/532/1542 Bias Binding sites Biology Biomedical and Life Sciences Cancer Research Cell Biology Cell fate Cells (biology) Chromatin Developmental Biology Endogenous Retroviruses Epigenetics Hematopoietic stem cells Life Sciences News & Views news-and-views Progenitor cells Stem Cells Thymus gland Transcriptomes |
| title | H3.3 safeguards haematopoietic ERV-quilibrium |
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