H3.3 safeguards haematopoietic ERV-quilibrium

H3.3 safeguards haematopoietic ERV-quilibrium

Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterati...

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Veröffentlicht in:Nature cell biology 2022-01, Vol.24 (1), p.7-9
Hauptverfasser: Cipta, Nadia Omega, Chen, Ying, Loh, Yuin-Han
Format: Artikel
Sprache:eng
Schlagworte:
631/337/176
631/532/1542
Bias
Binding sites
Biology
Biomedical and Life Sciences
Cancer Research
Cell Biology
Cell fate
Cells (biology)
Chromatin
Developmental Biology
Endogenous Retroviruses
Epigenetics
Hematopoietic stem cells
Life Sciences
News & Views
news-and-views
Progenitor cells
Stem Cells
Thymus gland
Transcriptomes
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Beschreibung
Zusammenfassung:Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterations.
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-021-00758-y