[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([F-18]NaF) to understand bone physiology. Dynamic [F-18]NaF PET scans...

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Veröffentlicht in:	Tomography (Ann Arbor) 2021-12, Vol.7 (4), p.843-854
Hauptverfasser:	Puri, Tanuj, Frost, Michelle L., Cook, Gary J., Blake, Glen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	[18F] sodium fluoride [18F]NaF computed tomography dynamic positron emission tomography Fluorine Radioisotopes Life Sciences & Biomedicine PET Positron-Emission Tomography - methods Radiology, Nuclear Medicine & Medical Imaging Review Science & Technology Sodium Fluoride - pharmacokinetics
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Beschreibung
Zusammenfassung:	This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([F-18]NaF) to understand bone physiology. Dynamic [F-18]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.
ISSN:	2379-1381 2379-139X 2379-139X
DOI:	10.3390/tomography7040071