Cutaneous β HPVs, Sun Exposure, and Risk of Squamous and Basal Cell Skin Cancers in Australia

Cutaneous β HPVs, Sun Exposure, and Risk of Squamous and Basal Cell Skin Cancers in Australia

Sun exposure causes cutaneous squamous (SCC) and basal cell (BCC) carcinomas. Human papillomavirus (HPV) infection might cause SCC. We examined associations of β and γ HPV infection in skin-swab DNA and serum antibodies with skin cancer risk, and modification of the carcinogenic effects of sun expos...

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Veröffentlicht in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2022-03, Vol.31 (3), p.614-624
Hauptverfasser: Kricker, Anne, Weber, Marianne F, Pawlita, Michael, Sitas, Freddy, Hodgkinson, Verity S, Rahman, Bayzidur, van Kemenade, Cathelijne H, Armstrong, Bruce K, Waterboer, Tim
Format: Artikel
Sprache:eng
Schlagworte:
Australia - epidemiology
Carcinoma, Basal Cell - epidemiology
Carcinoma, Basal Cell - etiology
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - etiology
Humans
Papillomaviridae - genetics
Papillomavirus Infections
Prospective Studies
Risk Factors
Skin Neoplasms - epidemiology
Skin Neoplasms - etiology
Sunlight - adverse effects
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Zusammenfassung:Sun exposure causes cutaneous squamous (SCC) and basal cell (BCC) carcinomas. Human papillomavirus (HPV) infection might cause SCC. We examined associations of β and γ HPV infection in skin-swab DNA and serum antibodies with skin cancer risk, and modification of the carcinogenic effects of sun exposure by them, in case-control studies of 385 SCC cases, 832 BCC cases, and 1,100 controls nested in an Australian prospective cohort study (enrolled 2006-2009). Presence of β-1 and β-3 HPV DNA appeared to increase risks for SCC and BCC by 30% to 40% (P adjusted
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-21-1000