Advanced liver fibrosis measured by transient elastography predicts chronic kidney disease development in individuals with non-alcoholic fatty liver disease

Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are progressive chronic conditions that share important cardiometabolic risk factors and pathogenic mechanisms. We investigated the association between liver fibrosis measured by transient elastography (TE) an...

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Veröffentlicht in:	Diabetologia 2022-03, Vol.65 (3), p.518-527
Hauptverfasser:	Jung, Chan-Young, Ryu, Geun Woo, Kim, Hyung Woo, Ahn, Sang Hoon, Kim, Seung Up, Kim, Beom Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic illnesses Elasticity Imaging Techniques - adverse effects Epidermal growth factor receptors Fatty liver Fibrosis Human Physiology Humans Internal Medicine Kidney diseases Liver Cirrhosis - diagnostic imaging Liver diseases Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Non-alcoholic Fatty Liver Disease - complications Proteinuria Renal Insufficiency, Chronic - epidemiology Risk factors
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Zusammenfassung:	Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are progressive chronic conditions that share important cardiometabolic risk factors and pathogenic mechanisms. We investigated the association between liver fibrosis measured by transient elastography (TE) and the risk of incident CKD in individuals with NAFLD. Methods A total of 5983 participants with NAFLD (defined as controlled attenuation parameter >222 dB/m) but without CKD who underwent TE between March 2012 and August 2018 were selected. The primary outcome was incident CKD, defined as the occurrence of eGFR
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-021-05627-9