Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia

•This study was a case-control study aimed to find out association of IL1R1rs2071374 with the risk of preeclampsia compared with normotensive pregnant women.•The presence of IL1R1rs2071374G allele was associated with the increased risk of preeclampsia•It is the first study to evaluate that IL1R1 polymorphism is correlated with preeclampsia pathogenesis in the Population in India. Association of IL1R1rs2071374 with the risk of preeclampsia compared with normotensive pregnant women. The study was a case-control study with 304 pregnant women comprising of preeclampsia (n = 152) and normotensive pregnancies (n = 152). And SNP rs2071374 was genotyped by PCR-RFLP method. The presence of IL1R1rs2071374G allele was associated with the increased risk of preeclampsia P = 0.01741, odds ratio = 0.7006 (95% CI: 0.5023-0.9759). The results indicated that there was an association in IL1R1 rs2071374SNP with preeclampsia compared to non-preeclampsia women. It is the first study to evaluate that IL1R1 polymorphism is correlated with preeclampsia pathogenesis in the Population in India.