Adult attachment style moderates the effect of oxytocin on neural responses to infant emotional faces

Oxytocin (OT) is known for its positive influence on maternal motivation and behavior, however, the effects of intranasal oxytocin (IN-OT) on neural activity during the perception of infant stimuli are often inconsistent. These discrepancies further reveal the need to take into account individual differences in IN-OT research. The present study aims to examine whether the effects of IN-OT on maternal-related neural responses to infant faces were moderated by participants' attachment style. Using a between-groups, double-blind, placebo-controlled design, 65 nulliparous females were randomly assigned to groups receiving a single dose of 24 IU oxytocin or a placebo via intranasal administration. The neural responses of participants were assessed during a facial recognition task with joy, neutral, and crying infant faces. The results indicated that females with high levels of attachment anxiety exhibited decreased right amygdala activity in response to infant joy faces and decreased bilateral insula activity in response to infant crying faces following IN-OT. Meanwhile, IN-OT enhanced bilateral amygdala and left inferior orbital frontal cortex (OFC) activity in response to infant crying faces in females with high levels of attachment avoidance. In addition, some beneficial effects of IN-OT were also observed in females with low levels of attachment avoidance or anxiety. Our findings demonstrated that the beneficial effects of IN-OT on neural responses to infant faces may depend on individual differences in adult attachment style, thereby contributing to our understanding of the role of OT in maternal caregiving. •The present study first demonstrates that the beneficial effect of intranasal oxytocin on neural responses to infant emotional faces was moderated by adult attachment styles in nulliparous women.•Our findings implicate that the beneficial effect of intranasal oxytocin is most obvious in individuals with high attachment avoidance and individuals with high attachment anxiety.•The present study provides empirical evidence that it is very meaningful to emphasize the adult attachment styles in the effect of intranasal oxytocin, which will contribute to our understanding of the complex role of oxytocin in social cognition.