Rolling the RBP snowballs

Rolling the RBP snowballs

The molecular mechanism through which chromatin-bound RNA-binding proteins (chrRBPs) control transcription remains obscure. A new study reveals that chrRBPs can compartmentalize RNA and transcription machinery into a phase-separated condensate, thus modulating gene expression.

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Bibliographische Detailangaben
Veröffentlicht in:Nature chemical biology 2022-01, Vol.18 (1), p.5-6
Hauptverfasser: Li, Chengyu, Lu, Huasong
Format: Artikel
Sprache:eng
Schlagworte:
631/337/572
631/92/500
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Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chromatin
Gene expression
News & Views
news-and-views
Ribonucleic acid
RNA
RNA-binding protein
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Beschreibung
Zusammenfassung:The molecular mechanism through which chromatin-bound RNA-binding proteins (chrRBPs) control transcription remains obscure. A new study reveals that chrRBPs can compartmentalize RNA and transcription machinery into a phase-separated condensate, thus modulating gene expression.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-021-00902-7