Squamous cell carcinoma of the rectum in an HIV-1 patient on antiretroviral therapy

Primary squamous cell carcinoma of the rectum is a very rare malignancy in clinical practice. There are only a few case-studies related to SCC rectum in HIV-1 infected persons in the literature. We report here a case in which the patient, in spite of receiving combination antiretroviral therapy and optimum virological control, suffered from SC C rectum. He was treated with chemoradiation but he relapsed soon and now receiving palliative treatment with Cisplatin and Fluorouracil. There are no case-reports on this issue from India and probably this is the first case-report on SCC rectum in HIV-1 infection adequately treated with cART. Since this is very aggressive disease, outcome is poor.