Size does matter: piRNA and miRNA targeting

Size does matter: piRNA and miRNA targeting

Piwi-interacting RNAs (piRNAs) guide PIWI proteins to bind and cleave RNAs. Originally, piRNAs were described as a system for transposable element repression. Recently, Anzelon, Choudhury, Hughes et al. uncovered the structural basis for piRNA targeting, whereby they are recognized in a manner disti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2022-04, Vol.47 (4), p.287-288
1. Verfasser: Marzec, Marek
Format: Artikel
Sprache:eng
Schlagworte:
Argonaute
Argonaute Proteins - metabolism
DNA Transposable Elements - genetics
MicroRNAs - genetics
miRNA
PIWI
piwi-interacting RNA
RNA binding
RNA, Small Interfering - metabolism
targeting
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Piwi-interacting RNAs (piRNAs) guide PIWI proteins to bind and cleave RNAs. Originally, piRNAs were described as a system for transposable element repression. Recently, Anzelon, Choudhury, Hughes et al. uncovered the structural basis for piRNA targeting, whereby they are recognized in a manner distinct from targeting by miRNAs.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2021.12.001