High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

Background The prostatic effects induced by arterial hypertension is very controversial and its mechanism is unclear. High‐intensity interval training (HIIT) is an exercise considered to be hypotensive. The objective of this work was to investigate the molecular, biochemical, and morphological effects of 8 weeks of HIIT in the prostatic tissue of spontaneously hypertensive rats (SHR). Methods Twenty male SHR rats, 51.4 weeks old, were used. The SHR animals were divided into two groups: spontaneously sedentary hypertensive and spontaneously hypertensive submitted to HIIT. We analyze androgens receptor and glucocorticoid receptors in the prostate. Still, we verify effects of the hypertension and HIIT on the physiopathology prostatic, for immunohistochemistry investigated BCL‐2, BAX, IGF‐1, FAS/CD95, data's inflammatory tumour necrosis factor α, nuclear factor kappa B and interleukin (IL)‐6, anti‐inflammatory IL‐10. The echocardiographic evaluation was performed at the baseline and after the training period. Results Arterial hypertension promote high prostatic intraepithelial neoplasia incidence in the prostate, increases IGF‐1, BCL‐2 (p