Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells
[Display omitted] •CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells. Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The...
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creator | Pagnan, Ana Lígia Pessoa, Adriano Souza Tokuhara, Cintia Kazuko Fakhoury, Vanessa Svizzero Oliveira, Gabriela Silva Neubern Sanches, Mariana Liessa Rovis Inacio, Kelly Karina Ximenes, Valdecir Farias Oliveira, Rodrigo Cardoso |
description | [Display omitted]
•CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells.
Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug. |
doi_str_mv | 10.1016/j.tice.2021.101705 |
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•CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells.
Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug.</description><identifier>ISSN: 0040-8166</identifier><identifier>EISSN: 1532-3072</identifier><identifier>DOI: 10.1016/j.tice.2021.101705</identifier><identifier>PMID: 34864499</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Animals ; Anticancer properties ; Antineoplastic Agents - pharmacology ; Antioxidants ; Antitumor agents ; Biomedical materials ; Bone cancer ; Bone Neoplasms - drug therapy ; Bone Neoplasms - metabolism ; Bone Neoplasms - pathology ; Caffeic acid ; Caffeic Acids - pharmacology ; Cancer ; Cell Line, Tumor ; Cell migration ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cytotoxicity ; Metastases ; Mice ; Osteosarcoma ; Osteosarcoma - drug therapy ; Osteosarcoma - metabolism ; Osteosarcoma - pathology ; Osteosarcoma cells ; Phenolic compounds ; Phenylethyl Alcohol - analogs & derivatives ; Phenylethyl Alcohol - pharmacology ; Phytochemicals ; Selectivity ; Tumor cells</subject><ispartof>Tissue & cell, 2022-02, Vol.74, p.101705-101705, Article 101705</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Feb 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-dab75e49972eb82ec5673b1941986894ad6b95e0bf451c61ecbfbe656cabd9c93</citedby><cites>FETCH-LOGICAL-c384t-dab75e49972eb82ec5673b1941986894ad6b95e0bf451c61ecbfbe656cabd9c93</cites><orcidid>0000-0003-3070-5960</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0040816621002214$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34864499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pagnan, Ana Lígia</creatorcontrib><creatorcontrib>Pessoa, Adriano Souza</creatorcontrib><creatorcontrib>Tokuhara, Cintia Kazuko</creatorcontrib><creatorcontrib>Fakhoury, Vanessa Svizzero</creatorcontrib><creatorcontrib>Oliveira, Gabriela Silva Neubern</creatorcontrib><creatorcontrib>Sanches, Mariana Liessa Rovis</creatorcontrib><creatorcontrib>Inacio, Kelly Karina</creatorcontrib><creatorcontrib>Ximenes, Valdecir Farias</creatorcontrib><creatorcontrib>Oliveira, Rodrigo Cardoso</creatorcontrib><title>Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells</title><title>Tissue & cell</title><addtitle>Tissue Cell</addtitle><description>[Display omitted]
•CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells.
Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug.</description><subject>Animals</subject><subject>Anticancer properties</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antioxidants</subject><subject>Antitumor agents</subject><subject>Biomedical materials</subject><subject>Bone cancer</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Caffeic acid</subject><subject>Caffeic Acids - pharmacology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cytotoxicity</subject><subject>Metastases</subject><subject>Mice</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - metabolism</subject><subject>Osteosarcoma - pathology</subject><subject>Osteosarcoma cells</subject><subject>Phenolic compounds</subject><subject>Phenylethyl Alcohol - analogs & derivatives</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Phytochemicals</subject><subject>Selectivity</subject><subject>Tumor cells</subject><issn>0040-8166</issn><issn>1532-3072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFTEUhoNY7LX6B1xIwE03c5uvyQe4KcWqUHCjKxchyZyhucxMrkmmcP-9GW514cJVPnjOy3sehN5RsqeEypvDvsYAe0YY3T4U6V-gHe056zhR7CXaESJIp6mUl-h1KQdCiBJUvUKXXGgphDE79PN2qbGr65zWjI-pQnu6CbtlwAUmCDU-xXrCacTBjSPEgF2IAz4-wgL18TRhKBUyjgtO7ZKKyyHNDgeYpvIGXYxuKvD2-bxCP-4_fb_70j18-_z17vahC1yL2g3Oqx5aG8XAawahl4p7agQ1Wmoj3CC96YH4UfQ0SArBjx5kL4PzgwmGX6Hrc-4xp19rK2TnWLYGboG0FsskUZxoo1RDP_yDHtriS2vXKK6ZoZqTRrEzFXIqJcNojznOLp8sJXZTbw92U2839fasvg29f45e_QzD35E_rhvw8QxAc_EUIdsSIiwBhpibaDuk-L_837xxlVo</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Pagnan, Ana Lígia</creator><creator>Pessoa, Adriano Souza</creator><creator>Tokuhara, Cintia Kazuko</creator><creator>Fakhoury, Vanessa Svizzero</creator><creator>Oliveira, Gabriela Silva Neubern</creator><creator>Sanches, Mariana Liessa Rovis</creator><creator>Inacio, Kelly Karina</creator><creator>Ximenes, Valdecir Farias</creator><creator>Oliveira, Rodrigo Cardoso</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3070-5960</orcidid></search><sort><creationdate>202202</creationdate><title>Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells</title><author>Pagnan, Ana Lígia ; Pessoa, Adriano Souza ; Tokuhara, Cintia Kazuko ; Fakhoury, Vanessa Svizzero ; Oliveira, Gabriela Silva Neubern ; Sanches, Mariana Liessa Rovis ; Inacio, Kelly Karina ; Ximenes, Valdecir Farias ; Oliveira, Rodrigo Cardoso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-dab75e49972eb82ec5673b1941986894ad6b95e0bf451c61ecbfbe656cabd9c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Anticancer properties</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antioxidants</topic><topic>Antitumor agents</topic><topic>Biomedical materials</topic><topic>Bone cancer</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Caffeic acid</topic><topic>Caffeic Acids - pharmacology</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cytotoxicity</topic><topic>Metastases</topic><topic>Mice</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - drug therapy</topic><topic>Osteosarcoma - metabolism</topic><topic>Osteosarcoma - pathology</topic><topic>Osteosarcoma cells</topic><topic>Phenolic compounds</topic><topic>Phenylethyl Alcohol - analogs & derivatives</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Phytochemicals</topic><topic>Selectivity</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pagnan, Ana Lígia</creatorcontrib><creatorcontrib>Pessoa, Adriano Souza</creatorcontrib><creatorcontrib>Tokuhara, Cintia Kazuko</creatorcontrib><creatorcontrib>Fakhoury, Vanessa Svizzero</creatorcontrib><creatorcontrib>Oliveira, Gabriela Silva Neubern</creatorcontrib><creatorcontrib>Sanches, Mariana Liessa Rovis</creatorcontrib><creatorcontrib>Inacio, Kelly Karina</creatorcontrib><creatorcontrib>Ximenes, Valdecir Farias</creatorcontrib><creatorcontrib>Oliveira, Rodrigo Cardoso</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue & cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pagnan, Ana Lígia</au><au>Pessoa, Adriano Souza</au><au>Tokuhara, Cintia Kazuko</au><au>Fakhoury, Vanessa Svizzero</au><au>Oliveira, Gabriela Silva Neubern</au><au>Sanches, Mariana Liessa Rovis</au><au>Inacio, Kelly Karina</au><au>Ximenes, Valdecir Farias</au><au>Oliveira, Rodrigo Cardoso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells</atitle><jtitle>Tissue & cell</jtitle><addtitle>Tissue Cell</addtitle><date>2022-02</date><risdate>2022</risdate><volume>74</volume><spage>101705</spage><epage>101705</epage><pages>101705-101705</pages><artnum>101705</artnum><issn>0040-8166</issn><eissn>1532-3072</eissn><abstract>[Display omitted]
•CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells.
Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>34864499</pmid><doi>10.1016/j.tice.2021.101705</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3070-5960</orcidid></addata></record> |
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subjects | Animals Anticancer properties Antineoplastic Agents - pharmacology Antioxidants Antitumor agents Biomedical materials Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Caffeic acid Caffeic Acids - pharmacology Cancer Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cytotoxicity Metastases Mice Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Osteosarcoma cells Phenolic compounds Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Phytochemicals Selectivity Tumor cells |
title | Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells |
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