Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells

[Display omitted] •CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells. Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The...

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Veröffentlicht in:Tissue & cell 2022-02, Vol.74, p.101705-101705, Article 101705
Hauptverfasser: Pagnan, Ana Lígia, Pessoa, Adriano Souza, Tokuhara, Cintia Kazuko, Fakhoury, Vanessa Svizzero, Oliveira, Gabriela Silva Neubern, Sanches, Mariana Liessa Rovis, Inacio, Kelly Karina, Ximenes, Valdecir Farias, Oliveira, Rodrigo Cardoso
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container_title Tissue & cell
container_volume 74
creator Pagnan, Ana Lígia
Pessoa, Adriano Souza
Tokuhara, Cintia Kazuko
Fakhoury, Vanessa Svizzero
Oliveira, Gabriela Silva Neubern
Sanches, Mariana Liessa Rovis
Inacio, Kelly Karina
Ximenes, Valdecir Farias
Oliveira, Rodrigo Cardoso
description [Display omitted] •CAPE decreased the viability cell compared to CA.•CAPE decreased ROS generation and cell migration.•CAPE was more selective for tumor cells, preserving normal cells. Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. In summary, CAPE was more selective for tumor cells, preserving normal ones, suggesting its potential role as an anticancer drug.
doi_str_mv 10.1016/j.tice.2021.101705
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Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p &lt; 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. 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Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the survival rate. The search for new therapeutic strategies has increased for phytochemicals due to their potential as antioxidants and anticancer properties. Thus, we evaluated the caffeic acid phenethyl ester (CAPE) and caffeic acid's (CA) anticancer properties on UMR-106 murine osteosarcoma cells. The IC25 and IC50 were 1.3 and 2.7 μM for CAPE and 91.0 and 120.0 μM for CA, respectively. This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p &lt; 0.05). In addition, CAPE was 44-fold (IC25) and 70-fold (IC50) more cytotoxic than CA. CAPE also decreased ROS generation and cell migration. 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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Anticancer properties
Antineoplastic Agents - pharmacology
Antioxidants
Antitumor agents
Biomedical materials
Bone cancer
Bone Neoplasms - drug therapy
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Caffeic acid
Caffeic Acids - pharmacology
Cancer
Cell Line, Tumor
Cell migration
Cell Movement - drug effects
Cell Proliferation - drug effects
Cell Survival - drug effects
Cytotoxicity
Metastases
Mice
Osteosarcoma
Osteosarcoma - drug therapy
Osteosarcoma - metabolism
Osteosarcoma - pathology
Osteosarcoma cells
Phenolic compounds
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Phytochemicals
Selectivity
Tumor cells
title Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells
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