Risk of incident cataract in patients with psoriasis: A population‐based cohort study
Patients with psoriasis are predisposed to ocular complications. However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoria...
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| Veröffentlicht in: | Journal of dermatology 2022-03, Vol.49 (3), p.359-367 |
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| description | Patients with psoriasis are predisposed to ocular complications. However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoriasis. The study subjects of this cohort study were selected based on Chang Gung Research Database from 1 January 2003 to 31 December 2012. Follow‐up ended 31 December 2017. Patients aged 20 years and older with psoriasis were enrolled. The participants of the control group were selected by matching with sex, age, and index date at a 4:1 ratio. Patients previously diagnosed with cataract were excluded. The hazard ratios associated with psoriasis were estimated using Cox regression analysis with competitive risk model. We also evaluated the relationship between the risk of cataract and systemic therapies as well as phototherapy and topical corticosteroid in patients with psoriasis. A total of 6823 patients with psoriasis and 27 292 matched controls were enrolled in the study. The psoriasis group had higher incidence rates than the control group for cataract (44.08 vs 19.45 per 10 000 person‐years; adjusted hazard ratio, 1.778 [95% confidence interval, 1.530–2.066; p |
| doi_str_mv | 10.1111/1346-8138.16261 |
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However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoriasis. The study subjects of this cohort study were selected based on Chang Gung Research Database from 1 January 2003 to 31 December 2012. Follow‐up ended 31 December 2017. Patients aged 20 years and older with psoriasis were enrolled. The participants of the control group were selected by matching with sex, age, and index date at a 4:1 ratio. Patients previously diagnosed with cataract were excluded. The hazard ratios associated with psoriasis were estimated using Cox regression analysis with competitive risk model. We also evaluated the relationship between the risk of cataract and systemic therapies as well as phototherapy and topical corticosteroid in patients with psoriasis. A total of 6823 patients with psoriasis and 27 292 matched controls were enrolled in the study. The psoriasis group had higher incidence rates than the control group for cataract (44.08 vs 19.45 per 10 000 person‐years; adjusted hazard ratio, 1.778 [95% confidence interval, 1.530–2.066; p < 0.001]). Psoriatic patients receiving phototherapy for more than 200 sessions had a higher risk of cataract (adjusted hazard ratio, 2.933; 95% confidence interval, 1.192–7.218; p = 0.019), especially those receiving narrowband ultraviolet B therapy. The present study demonstrated a positive association between psoriasis and cataract. Physicians should be alert to visual function in patients with psoriasis, especially those receiving long‐term phototherapy.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.16261</identifier><identifier>PMID: 34862667</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; cataract ; Cataract - epidemiology ; Cataract - etiology ; Cohort analysis ; Cohort Studies ; cohort study ; Confidence intervals ; Corticosteroids ; Humans ; Incidence ; Light therapy ; Phototherapy ; Population studies ; Population-based studies ; Psoriasis ; Psoriasis - complications ; Psoriasis - epidemiology ; Psoriasis - therapy ; Psoriatic arthritis ; Retrospective Studies ; Risk Factors ; Ultraviolet Therapy - adverse effects ; Visual perception ; Young Adult</subject><ispartof>Journal of dermatology, 2022-03, Vol.49 (3), p.359-367</ispartof><rights>2021 Japanese Dermatological Association</rights><rights>2021 Japanese Dermatological Association.</rights><rights>Copyright © 2022 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3951-3150c5773a75bd5c67ac6459f36639781555cb43bfb2119630d145db04155c043</citedby><cites>FETCH-LOGICAL-c3951-3150c5773a75bd5c67ac6459f36639781555cb43bfb2119630d145db04155c043</cites><orcidid>0000-0002-3746-9561</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.16261$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.16261$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34862667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Chun‐Yu</creatorcontrib><title>Risk of incident cataract in patients with psoriasis: A population‐based cohort study</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Patients with psoriasis are predisposed to ocular complications. However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoriasis. The study subjects of this cohort study were selected based on Chang Gung Research Database from 1 January 2003 to 31 December 2012. Follow‐up ended 31 December 2017. Patients aged 20 years and older with psoriasis were enrolled. The participants of the control group were selected by matching with sex, age, and index date at a 4:1 ratio. Patients previously diagnosed with cataract were excluded. The hazard ratios associated with psoriasis were estimated using Cox regression analysis with competitive risk model. We also evaluated the relationship between the risk of cataract and systemic therapies as well as phototherapy and topical corticosteroid in patients with psoriasis. A total of 6823 patients with psoriasis and 27 292 matched controls were enrolled in the study. The psoriasis group had higher incidence rates than the control group for cataract (44.08 vs 19.45 per 10 000 person‐years; adjusted hazard ratio, 1.778 [95% confidence interval, 1.530–2.066; p < 0.001]). Psoriatic patients receiving phototherapy for more than 200 sessions had a higher risk of cataract (adjusted hazard ratio, 2.933; 95% confidence interval, 1.192–7.218; p = 0.019), especially those receiving narrowband ultraviolet B therapy. The present study demonstrated a positive association between psoriasis and cataract. Physicians should be alert to visual function in patients with psoriasis, especially those receiving long‐term phototherapy.</description><subject>Adult</subject><subject>cataract</subject><subject>Cataract - epidemiology</subject><subject>Cataract - etiology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>cohort study</subject><subject>Confidence intervals</subject><subject>Corticosteroids</subject><subject>Humans</subject><subject>Incidence</subject><subject>Light therapy</subject><subject>Phototherapy</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Psoriasis</subject><subject>Psoriasis - complications</subject><subject>Psoriasis - epidemiology</subject><subject>Psoriasis - therapy</subject><subject>Psoriatic arthritis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Ultraviolet Therapy - adverse effects</subject><subject>Visual perception</subject><subject>Young Adult</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1OwzAYRS0EoqUwsyFLLCwpdvyThK0q5U-VkBCI0XIcR3VJ42AnqrrxCDwjT4JLSwcWvFi63_H1pwPAKUZDHM4lJpRHKSbpEPOY4z3Q3yX7oI9IyqKYoqQHjryfIxRnDKND0CM0DThP-uD1yfg3aEtoamUKXbdQyVY6qdqQwEa2JmQeLk07g423zkhv_BUcwcY2XRXGtv76-Myl1wVUdmZdC33bFatjcFDKyuuT7T0ALzeT5_FdNH28vR-PppEiYZeIYIYUSxIiE5YXTPFEKk5ZVhLOSZakmDGmckryMo8xzjhBBaasyBENE4UoGYCLTW_j7HunfSsWxitdVbLWtvMi5ohn4ZeUBfT8Dzq3navDdoEK1lKMkzRQlxtKOeu906VonFlItxIYibVzsTYs1obFj_Pw4mzb2-ULXez4X8kBYBtgaSq9-q9PPFxPNsXfQ3iKHg</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Cheng, Chun‐Yu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3746-9561</orcidid></search><sort><creationdate>202203</creationdate><title>Risk of incident cataract in patients with psoriasis: A population‐based cohort study</title><author>Cheng, Chun‐Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3951-3150c5773a75bd5c67ac6459f36639781555cb43bfb2119630d145db04155c043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>cataract</topic><topic>Cataract - epidemiology</topic><topic>Cataract - etiology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>cohort study</topic><topic>Confidence intervals</topic><topic>Corticosteroids</topic><topic>Humans</topic><topic>Incidence</topic><topic>Light therapy</topic><topic>Phototherapy</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Psoriasis</topic><topic>Psoriasis - complications</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - therapy</topic><topic>Psoriatic arthritis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Ultraviolet Therapy - adverse effects</topic><topic>Visual perception</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Chun‐Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Chun‐Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of incident cataract in patients with psoriasis: A population‐based cohort study</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2022-03</date><risdate>2022</risdate><volume>49</volume><issue>3</issue><spage>359</spage><epage>367</epage><pages>359-367</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Patients with psoriasis are predisposed to ocular complications. However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoriasis. The study subjects of this cohort study were selected based on Chang Gung Research Database from 1 January 2003 to 31 December 2012. Follow‐up ended 31 December 2017. Patients aged 20 years and older with psoriasis were enrolled. The participants of the control group were selected by matching with sex, age, and index date at a 4:1 ratio. Patients previously diagnosed with cataract were excluded. The hazard ratios associated with psoriasis were estimated using Cox regression analysis with competitive risk model. We also evaluated the relationship between the risk of cataract and systemic therapies as well as phototherapy and topical corticosteroid in patients with psoriasis. A total of 6823 patients with psoriasis and 27 292 matched controls were enrolled in the study. The psoriasis group had higher incidence rates than the control group for cataract (44.08 vs 19.45 per 10 000 person‐years; adjusted hazard ratio, 1.778 [95% confidence interval, 1.530–2.066; p < 0.001]). Psoriatic patients receiving phototherapy for more than 200 sessions had a higher risk of cataract (adjusted hazard ratio, 2.933; 95% confidence interval, 1.192–7.218; p = 0.019), especially those receiving narrowband ultraviolet B therapy. The present study demonstrated a positive association between psoriasis and cataract. Physicians should be alert to visual function in patients with psoriasis, especially those receiving long‐term phototherapy.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34862667</pmid><doi>10.1111/1346-8138.16261</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3746-9561</orcidid></addata></record> |
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| subjects | Adult cataract Cataract - epidemiology Cataract - etiology Cohort analysis Cohort Studies cohort study Confidence intervals Corticosteroids Humans Incidence Light therapy Phototherapy Population studies Population-based studies Psoriasis Psoriasis - complications Psoriasis - epidemiology Psoriasis - therapy Psoriatic arthritis Retrospective Studies Risk Factors Ultraviolet Therapy - adverse effects Visual perception Young Adult |
| title | Risk of incident cataract in patients with psoriasis: A population‐based cohort study |
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