Risk of incident cataract in patients with psoriasis: A population‐based cohort study

Patients with psoriasis are predisposed to ocular complications. However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoria...

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Veröffentlicht in:Journal of dermatology 2022-03, Vol.49 (3), p.359-367
1. Verfasser: Cheng, Chun‐Yu
Format: Artikel
Sprache:eng
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Zusammenfassung:Patients with psoriasis are predisposed to ocular complications. However, there is a paucity of data addressing the association between psoriasis and subsequent cataract development. The present study was conducted to evaluate whether there is an increased risk of cataract among patients with psoriasis. The study subjects of this cohort study were selected based on Chang Gung Research Database from 1 January 2003 to 31 December 2012. Follow‐up ended 31 December 2017. Patients aged 20 years and older with psoriasis were enrolled. The participants of the control group were selected by matching with sex, age, and index date at a 4:1 ratio. Patients previously diagnosed with cataract were excluded. The hazard ratios associated with psoriasis were estimated using Cox regression analysis with competitive risk model. We also evaluated the relationship between the risk of cataract and systemic therapies as well as phototherapy and topical corticosteroid in patients with psoriasis. A total of 6823 patients with psoriasis and 27 292 matched controls were enrolled in the study. The psoriasis group had higher incidence rates than the control group for cataract (44.08 vs 19.45 per 10 000 person‐years; adjusted hazard ratio, 1.778 [95% confidence interval, 1.530–2.066; p 
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.16261