Injectable nanocomposite hydrogels as an emerging platform for biomedical applications: A review

Hydrogels have attracted much attention for biomedical and pharmaceutical applications due to the similarity of their biomimetic structure to the extracellular matrix of natural living tissues, tunable soft porous microarchitecture, superb biomechanical properties, proper biocompatibility, etc. Injectable hydrogels are an exciting type of hydrogels that can be easily injected into the target sites using needles or catheters in a minimally invasive manner. The more comfortable use, less pain, faster recovery period, lower costs, and fewer side effects make injectable hydrogels more attractive to both patients and clinicians in comparison to non-injectable hydrogels. However, it is difficult to achieve an ideal injectable hydrogel using just a single material (i.e., polymer). This challenge can be overcome by incorporating nanofillers into the polymeric matrix to engineer injectable nanocomposite hydrogels with combined or synergistic properties gained from the constituents. This work aims to critically review injectable nanocomposite hydrogels, their preparation methods, properties, functionalities, and versatile biomedical and pharmaceutical applications such as tissue engineering, drug delivery, and cancer labeling and therapy. The most common natural and synthetic polymers as matrices together with the most popular nanomaterials as reinforcements, including nanoceramics, carbon-based nanostructures, metallic nanomaterials, and various nanosized polymeric materials, are highlighted in this review. [Display omitted] •Injectable nanocomposite hydrogels combine benefits of biomimetic hydrogels, injectable materials, and nanomaterials.•Various natural and synthetic polymers as matrices and nanomaterials as reinforcements are summarized.•Rationales behind the selection of matrices and nanofillers are discussed.•Mechanisms of gelation along with physicochemical, mechanical, and biological behavior of the resulting hydrogels are highlighted.•Biomedical applications of the injectable nanocomposite hydrogels such as tissue engineering, drug delivery, and cancer labeling and therapy are explained.