Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

•This ESMO Clinical Practice Guideline provides key recommendations for managing malignant pleural mesothelioma.•The optimal diagnostic methods, pathological evaluation and staging are described.•The authors make recommendations on the role of surgery and macroscopic complete resection as part of multimodality therapy.•The authors discuss optimal first-line, maintenance and salvage systemic therapies and immune checkpoint inhibitors.•The authors discuss the role of prophylactic, radical and palliative radiotherapy and optimal supportive care.