Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice
The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 2021/12/01, Vol.44(12), pp.1894-1897 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1897 |
|---|---|
| container_issue | 12 |
| container_start_page | 1894 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 44 |
| creator | Hamaguchi, Shogo Abe, Kohei Komatsu, Momoka Kainuma, Jun Namekata, Iyuki Tanaka, Hikaru |
| description | The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and diabetic myocardia. This effect of quercetin was completely inhibited by cyclopiazonic acid but not by SEA0400. These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco–endoplasmic reticulum Ca2+-ATPase. |
| doi_str_mv | 10.1248/bpb.b21-00580 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2605601571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2605601571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-cea636dac82e02042b4e8fd7d5d81044d042b0a874729d6fa8bd11147888a60d3</originalsourceid><addsrcrecordid>eNpdkUmP1DAQhSMEYpqBI1dkiQuXDN4SO0c0Gy31sIjlajl2BdxK7B7bQZo58NtxuodG4lK2XF-9evKrqpcEnxHK5dt-15_1lNQYNxI_qlaEcVE3lDSPqxXuiKxb0siT6llKW4yxwJQ9rU4Ylw2jgq-q359Cctn9ArSZyyWGnTPochjAZBQG9HmGaCA7j4JH6xRGncGi7-BzdGYedUQ3d8HoaJ1GQwwT-hDipEekvUVfcoRdDvchB-N8vfZ2NmX4wum-KBp04ww8r54Mekzw4uE8rb5dXX49f19vPl6vz99tatM2Xa4N6Ja1VhtJAVPMac9BDlbYxkqCObfLE9ZScEE72w5a9pYQwoWUUrfYstPqzUF3F8PtDCmrySUD46g9hDkp2uKmxaQRpKCv_0O3YY6-uNtTjDLSykLVB8rEkFKEQe2im3S8UwSrJRhVglElGLUPpvCvHlTnfgJ7pP8mUYDrA1C6zugx-NF5-LfbJNG7MAZF8V6Uc0JVcayI7PhSBOsoYXRZdXFQ2qasf8BxlY7l10fYG-NlhC716PDYNj91VODZHwEOuHM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2605323168</pqid></control><display><type>article</type><title>Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Hamaguchi, Shogo ; Abe, Kohei ; Komatsu, Momoka ; Kainuma, Jun ; Namekata, Iyuki ; Tanaka, Hikaru</creator><creatorcontrib>Hamaguchi, Shogo ; Abe, Kohei ; Komatsu, Momoka ; Kainuma, Jun ; Namekata, Iyuki ; Tanaka, Hikaru ; Department of Pharmacology ; Toho University Faculty of Pharmaceutical Sciences</creatorcontrib><description>The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and diabetic myocardia. This effect of quercetin was completely inhibited by cyclopiazonic acid but not by SEA0400. These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco–endoplasmic reticulum Ca2+-ATPase.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b21-00580</identifier><identifier>PMID: 34853274</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Adenosine triphosphatase ; Adenosine Triphosphatases - metabolism ; Aniline Compounds - pharmacology ; Animals ; Ca2+-transporting ATPase ; Calcium (reticular) ; Calcium - metabolism ; Cyclopiazonic acid ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; Endoplasmic Reticulum ; Enzyme Inhibitors ; Heart Ventricles - metabolism ; Heart Ventricles - physiopathology ; Indoles - pharmacology ; lusitropy ; Male ; Mice ; Myocardial Contraction - drug effects ; Myocardium ; Myocardium - metabolism ; Myocardium - pathology ; Phenyl Ethers - pharmacology ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plants, Edible - chemistry ; Quercetin ; Quercetin - pharmacology ; Quercetin - therapeutic use ; Reference Values ; Rodents ; sarco–endoplasmic reticulum Ca2+-ATPase ; Streptozocin ; Ventricle ; Ventricular Dysfunction, Left - etiology ; Ventricular Pressure</subject><ispartof>Biological and Pharmaceutical Bulletin, 2021/12/01, Vol.44(12), pp.1894-1897</ispartof><rights>2021 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-cea636dac82e02042b4e8fd7d5d81044d042b0a874729d6fa8bd11147888a60d3</citedby><cites>FETCH-LOGICAL-c659t-cea636dac82e02042b4e8fd7d5d81044d042b0a874729d6fa8bd11147888a60d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34853274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamaguchi, Shogo</creatorcontrib><creatorcontrib>Abe, Kohei</creatorcontrib><creatorcontrib>Komatsu, Momoka</creatorcontrib><creatorcontrib>Kainuma, Jun</creatorcontrib><creatorcontrib>Namekata, Iyuki</creatorcontrib><creatorcontrib>Tanaka, Hikaru</creatorcontrib><creatorcontrib>Department of Pharmacology</creatorcontrib><creatorcontrib>Toho University Faculty of Pharmaceutical Sciences</creatorcontrib><title>Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and diabetic myocardia. This effect of quercetin was completely inhibited by cyclopiazonic acid but not by SEA0400. These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco–endoplasmic reticulum Ca2+-ATPase.</description><subject>Adenosine triphosphatase</subject><subject>Adenosine Triphosphatases - metabolism</subject><subject>Aniline Compounds - pharmacology</subject><subject>Animals</subject><subject>Ca2+-transporting ATPase</subject><subject>Calcium (reticular)</subject><subject>Calcium - metabolism</subject><subject>Cyclopiazonic acid</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Endoplasmic Reticulum</subject><subject>Enzyme Inhibitors</subject><subject>Heart Ventricles - metabolism</subject><subject>Heart Ventricles - physiopathology</subject><subject>Indoles - pharmacology</subject><subject>lusitropy</subject><subject>Male</subject><subject>Mice</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardium</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Phenyl Ethers - pharmacology</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plants, Edible - chemistry</subject><subject>Quercetin</subject><subject>Quercetin - pharmacology</subject><subject>Quercetin - therapeutic use</subject><subject>Reference Values</subject><subject>Rodents</subject><subject>sarco–endoplasmic reticulum Ca2+-ATPase</subject><subject>Streptozocin</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Pressure</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUmP1DAQhSMEYpqBI1dkiQuXDN4SO0c0Gy31sIjlajl2BdxK7B7bQZo58NtxuodG4lK2XF-9evKrqpcEnxHK5dt-15_1lNQYNxI_qlaEcVE3lDSPqxXuiKxb0siT6llKW4yxwJQ9rU4Ylw2jgq-q359Cctn9ArSZyyWGnTPochjAZBQG9HmGaCA7j4JH6xRGncGi7-BzdGYedUQ3d8HoaJ1GQwwT-hDipEekvUVfcoRdDvchB-N8vfZ2NmX4wum-KBp04ww8r54Mekzw4uE8rb5dXX49f19vPl6vz99tatM2Xa4N6Ja1VhtJAVPMac9BDlbYxkqCObfLE9ZScEE72w5a9pYQwoWUUrfYstPqzUF3F8PtDCmrySUD46g9hDkp2uKmxaQRpKCv_0O3YY6-uNtTjDLSykLVB8rEkFKEQe2im3S8UwSrJRhVglElGLUPpvCvHlTnfgJ7pP8mUYDrA1C6zugx-NF5-LfbJNG7MAZF8V6Uc0JVcayI7PhSBOsoYXRZdXFQ2qasf8BxlY7l10fYG-NlhC716PDYNj91VODZHwEOuHM</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Hamaguchi, Shogo</creator><creator>Abe, Kohei</creator><creator>Komatsu, Momoka</creator><creator>Kainuma, Jun</creator><creator>Namekata, Iyuki</creator><creator>Tanaka, Hikaru</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice</title><author>Hamaguchi, Shogo ; Abe, Kohei ; Komatsu, Momoka ; Kainuma, Jun ; Namekata, Iyuki ; Tanaka, Hikaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-cea636dac82e02042b4e8fd7d5d81044d042b0a874729d6fa8bd11147888a60d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenosine triphosphatase</topic><topic>Adenosine Triphosphatases - metabolism</topic><topic>Aniline Compounds - pharmacology</topic><topic>Animals</topic><topic>Ca2+-transporting ATPase</topic><topic>Calcium (reticular)</topic><topic>Calcium - metabolism</topic><topic>Cyclopiazonic acid</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Endoplasmic Reticulum</topic><topic>Enzyme Inhibitors</topic><topic>Heart Ventricles - metabolism</topic><topic>Heart Ventricles - physiopathology</topic><topic>Indoles - pharmacology</topic><topic>lusitropy</topic><topic>Male</topic><topic>Mice</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardium</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Phenyl Ethers - pharmacology</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plants, Edible - chemistry</topic><topic>Quercetin</topic><topic>Quercetin - pharmacology</topic><topic>Quercetin - therapeutic use</topic><topic>Reference Values</topic><topic>Rodents</topic><topic>sarco–endoplasmic reticulum Ca2+-ATPase</topic><topic>Streptozocin</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamaguchi, Shogo</creatorcontrib><creatorcontrib>Abe, Kohei</creatorcontrib><creatorcontrib>Komatsu, Momoka</creatorcontrib><creatorcontrib>Kainuma, Jun</creatorcontrib><creatorcontrib>Namekata, Iyuki</creatorcontrib><creatorcontrib>Tanaka, Hikaru</creatorcontrib><creatorcontrib>Department of Pharmacology</creatorcontrib><creatorcontrib>Toho University Faculty of Pharmaceutical Sciences</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamaguchi, Shogo</au><au>Abe, Kohei</au><au>Komatsu, Momoka</au><au>Kainuma, Jun</au><au>Namekata, Iyuki</au><au>Tanaka, Hikaru</au><aucorp>Department of Pharmacology</aucorp><aucorp>Toho University Faculty of Pharmaceutical Sciences</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>44</volume><issue>12</issue><spage>1894</spage><epage>1897</epage><pages>1894-1897</pages><artnum>b21-00580</artnum><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and diabetic myocardia. This effect of quercetin was completely inhibited by cyclopiazonic acid but not by SEA0400. These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco–endoplasmic reticulum Ca2+-ATPase.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>34853274</pmid><doi>10.1248/bpb.b21-00580</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2021/12/01, Vol.44(12), pp.1894-1897 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2605601571 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adenosine triphosphatase Adenosine Triphosphatases - metabolism Aniline Compounds - pharmacology Animals Ca2+-transporting ATPase Calcium (reticular) Calcium - metabolism Cyclopiazonic acid Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Endoplasmic Reticulum Enzyme Inhibitors Heart Ventricles - metabolism Heart Ventricles - physiopathology Indoles - pharmacology lusitropy Male Mice Myocardial Contraction - drug effects Myocardium Myocardium - metabolism Myocardium - pathology Phenyl Ethers - pharmacology Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Edible - chemistry Quercetin Quercetin - pharmacology Quercetin - therapeutic use Reference Values Rodents sarco–endoplasmic reticulum Ca2+-ATPase Streptozocin Ventricle Ventricular Dysfunction, Left - etiology Ventricular Pressure |
| title | Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T08%3A23%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Positive%20Lusitropic%20Effect%20of%20Quercetin%20on%20Isolated%20Ventricular%20Myocardia%20from%20Normal%20and%20Streptozotocin-Induced%20Diabetic%20Mice&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=Hamaguchi,%20Shogo&rft.aucorp=Department%20of%20Pharmacology&rft.date=2021-12-01&rft.volume=44&rft.issue=12&rft.spage=1894&rft.epage=1897&rft.pages=1894-1897&rft.artnum=b21-00580&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.b21-00580&rft_dat=%3Cproquest_cross%3E2605601571%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2605323168&rft_id=info:pmid/34853274&rfr_iscdi=true |