Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice

The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/12/01, Vol.44(12), pp.1894-1897
Hauptverfasser:	Hamaguchi, Shogo, Abe, Kohei, Komatsu, Momoka, Kainuma, Jun, Namekata, Iyuki, Tanaka, Hikaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - metabolism Aniline Compounds - pharmacology Animals Ca2+-transporting ATPase Calcium (reticular) Calcium - metabolism Cyclopiazonic acid Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Endoplasmic Reticulum Enzyme Inhibitors Heart Ventricles - metabolism Heart Ventricles - physiopathology Indoles - pharmacology lusitropy Male Mice Myocardial Contraction - drug effects Myocardium Myocardium - metabolism Myocardium - pathology Phenyl Ethers - pharmacology Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Edible - chemistry Quercetin Quercetin - pharmacology Quercetin - therapeutic use Reference Values Rodents sarco–endoplasmic reticulum Ca2+-ATPase Streptozocin Ventricle Ventricular Dysfunction, Left - etiology Ventricular Pressure
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Zusammenfassung:	The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and diabetic myocardia. This effect of quercetin was completely inhibited by cyclopiazonic acid but not by SEA0400. These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco–endoplasmic reticulum Ca2+-ATPase.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.b21-00580