Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population
We aim to investigate the long-term adverse effects of polycyclic aromatic hydrocarbons (PAHs) exposure on heart rate variability (HRV) reduction, and to assess the potential role of transforming growth factor-β1 (TGF-β1) in such relationship. We enrolled 2985 adult residents with 4100 observations...
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| Veröffentlicht in: | Journal of hazardous materials 2022-03, Vol.425, p.127770-127770, Article 127770 |
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| creator | Ma, Jixuan Tan, Qiyou Nie, Xiuquan Zhou, Min Wang, Bin Wang, Xing Cheng, Man Ye, Zi Xie, Yujia Wang, Dongming Chen, Weihong |
| description | We aim to investigate the long-term adverse effects of polycyclic aromatic hydrocarbons (PAHs) exposure on heart rate variability (HRV) reduction, and to assess the potential role of transforming growth factor-β1 (TGF-β1) in such relationship. We enrolled 2985 adult residents with 4100 observations who participated at baseline and 6-years follow-up from Wuhan-Zhuhai cohort. Ten detectable urinary PAHs metabolites and two HRV indices were repeatedly measured at baseline and follow-up; and plasma TGF-β1 levels were also determined for all subjects. We observed that both total urinary low molecular weight PAHs (ΣLWM OH-PAH) and total urinary high molecular weight PAHs (ΣHWM OH-PAH) were negatively associated with HRV reductions (P |
| doi_str_mv | 10.1016/j.jhazmat.2021.127770 |
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•Long-term exposure of PAHs may cause HRV reductions over 6 years.•TGF-β1 aggravate HRV reductions caused by PAHs exposure over 6 years.•TGF-β1 may be a possible mechanism underlying the reduction of HRV caused by PAHs.</description><identifier>ISSN: 0304-3894</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2021.127770</identifier><identifier>PMID: 34823955</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Biomarkers ; Cardiovascular disease ; China ; Environmental pollutants ; Heart Rate ; HRV ; Humans ; PAHs ; Polycyclic Aromatic Hydrocarbons - toxicity ; TGF-β ; Transforming Growth Factor beta ; Transforming Growth Factors</subject><ispartof>Journal of hazardous materials, 2022-03, Vol.425, p.127770-127770, Article 127770</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-135987ef824a35ab5047acde820f7255d4a04ce25e82af2ce3b3edba2912cdb53</citedby><cites>FETCH-LOGICAL-c365t-135987ef824a35ab5047acde820f7255d4a04ce25e82af2ce3b3edba2912cdb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhazmat.2021.127770$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34823955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Jixuan</creatorcontrib><creatorcontrib>Tan, Qiyou</creatorcontrib><creatorcontrib>Nie, Xiuquan</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Cheng, Man</creatorcontrib><creatorcontrib>Ye, Zi</creatorcontrib><creatorcontrib>Xie, Yujia</creatorcontrib><creatorcontrib>Wang, Dongming</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><title>Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>We aim to investigate the long-term adverse effects of polycyclic aromatic hydrocarbons (PAHs) exposure on heart rate variability (HRV) reduction, and to assess the potential role of transforming growth factor-β1 (TGF-β1) in such relationship. We enrolled 2985 adult residents with 4100 observations who participated at baseline and 6-years follow-up from Wuhan-Zhuhai cohort. Ten detectable urinary PAHs metabolites and two HRV indices were repeatedly measured at baseline and follow-up; and plasma TGF-β1 levels were also determined for all subjects. We observed that both total urinary low molecular weight PAHs (ΣLWM OH-PAH) and total urinary high molecular weight PAHs (ΣHWM OH-PAH) were negatively associated with HRV reductions (P < 0.05). Subjects with persistent high levels of ΣHWM OH-PAH had a significant reduction in HRV over 6 years, and the incensement of TGF-β1 could aggravate above adverse effects in a dose-response manner. All kinds of PAHs were positively associated with plasma TGF-β1 elevation, which in turn, were negatively related to HRV indices. Increased TGF-β1 significant mediated 1.34–3.62% of PAHs-associated HRV reduction. Our findings demonstrated that long-term high levels of PAHs exposure could cause HRV reductions, and TGF-β1 may play an essential role in such association.
[Display omitted]
•Long-term exposure of PAHs may cause HRV reductions over 6 years.•TGF-β1 aggravate HRV reductions caused by PAHs exposure over 6 years.•TGF-β1 may be a possible mechanism underlying the reduction of HRV caused by PAHs.</description><subject>Adult</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>China</subject><subject>Environmental pollutants</subject><subject>Heart Rate</subject><subject>HRV</subject><subject>Humans</subject><subject>PAHs</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>TGF-β</subject><subject>Transforming Growth Factor beta</subject><subject>Transforming Growth Factors</subject><issn>0304-3894</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-O0zAQxiMEYsvCI4B85JLiP3GTckGoWhakSlzgbE2cSeMqtcPY2d3yNDwDdy77ADwTXrVw5eSR55v5PvtXFC8FXwouVm_2y_0A3w-QlpJLsRSyrmv-qFiIplalUmr1uFhwxatSNevqongW455zLmpdPS0uVNVItdZ6UfzaBr9zae6ch5ERjpBc8HFwU2QtpltEz6YwHu3Rjs4yoJAtczEcOwoWqM1ihndTiDMhA9-xAYESI0jIboActG506fiWXd1NYyDndywNyCiMyELPEoGPfaBDbtz_2FG4TQPrwaZA5e-fzHkGbIceKafbDM5jxJxnmk85nxdPehgjvjifl8XXD1dfNh_L7efrT5v329KqlU6lUHrd1Ng3sgKlodW8qsF22Eje11LrrgJeWZQ630AvLapWYdeCXAtpu1ary-L1ae9E4duMMZmDixbHETyGORq54lX-WyHqLNUnqaUQI2FvJnIHoKMR3DyQM3tzJmceyJkTuTz36mwxtwfs_k39RZUF704CzA-9cUgmWofeYucIbTJdcP-x-ANwyLTy</recordid><startdate>20220305</startdate><enddate>20220305</enddate><creator>Ma, Jixuan</creator><creator>Tan, Qiyou</creator><creator>Nie, Xiuquan</creator><creator>Zhou, Min</creator><creator>Wang, Bin</creator><creator>Wang, Xing</creator><creator>Cheng, Man</creator><creator>Ye, Zi</creator><creator>Xie, Yujia</creator><creator>Wang, Dongming</creator><creator>Chen, Weihong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220305</creationdate><title>Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population</title><author>Ma, Jixuan ; Tan, Qiyou ; Nie, Xiuquan ; Zhou, Min ; Wang, Bin ; Wang, Xing ; Cheng, Man ; Ye, Zi ; Xie, Yujia ; Wang, Dongming ; Chen, Weihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-135987ef824a35ab5047acde820f7255d4a04ce25e82af2ce3b3edba2912cdb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>China</topic><topic>Environmental pollutants</topic><topic>Heart Rate</topic><topic>HRV</topic><topic>Humans</topic><topic>PAHs</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>TGF-β</topic><topic>Transforming Growth Factor beta</topic><topic>Transforming Growth Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Jixuan</creatorcontrib><creatorcontrib>Tan, Qiyou</creatorcontrib><creatorcontrib>Nie, Xiuquan</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Cheng, Man</creatorcontrib><creatorcontrib>Ye, Zi</creatorcontrib><creatorcontrib>Xie, Yujia</creatorcontrib><creatorcontrib>Wang, Dongming</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Jixuan</au><au>Tan, Qiyou</au><au>Nie, Xiuquan</au><au>Zhou, Min</au><au>Wang, Bin</au><au>Wang, Xing</au><au>Cheng, Man</au><au>Ye, Zi</au><au>Xie, Yujia</au><au>Wang, Dongming</au><au>Chen, Weihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2022-03-05</date><risdate>2022</risdate><volume>425</volume><spage>127770</spage><epage>127770</epage><pages>127770-127770</pages><artnum>127770</artnum><issn>0304-3894</issn><eissn>1873-3336</eissn><abstract>We aim to investigate the long-term adverse effects of polycyclic aromatic hydrocarbons (PAHs) exposure on heart rate variability (HRV) reduction, and to assess the potential role of transforming growth factor-β1 (TGF-β1) in such relationship. We enrolled 2985 adult residents with 4100 observations who participated at baseline and 6-years follow-up from Wuhan-Zhuhai cohort. Ten detectable urinary PAHs metabolites and two HRV indices were repeatedly measured at baseline and follow-up; and plasma TGF-β1 levels were also determined for all subjects. We observed that both total urinary low molecular weight PAHs (ΣLWM OH-PAH) and total urinary high molecular weight PAHs (ΣHWM OH-PAH) were negatively associated with HRV reductions (P < 0.05). Subjects with persistent high levels of ΣHWM OH-PAH had a significant reduction in HRV over 6 years, and the incensement of TGF-β1 could aggravate above adverse effects in a dose-response manner. All kinds of PAHs were positively associated with plasma TGF-β1 elevation, which in turn, were negatively related to HRV indices. Increased TGF-β1 significant mediated 1.34–3.62% of PAHs-associated HRV reduction. Our findings demonstrated that long-term high levels of PAHs exposure could cause HRV reductions, and TGF-β1 may play an essential role in such association.
[Display omitted]
•Long-term exposure of PAHs may cause HRV reductions over 6 years.•TGF-β1 aggravate HRV reductions caused by PAHs exposure over 6 years.•TGF-β1 may be a possible mechanism underlying the reduction of HRV caused by PAHs.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34823955</pmid><doi>10.1016/j.jhazmat.2021.127770</doi><tpages>1</tpages></addata></record> |
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| subjects | Adult Biomarkers Cardiovascular disease China Environmental pollutants Heart Rate HRV Humans PAHs Polycyclic Aromatic Hydrocarbons - toxicity TGF-β Transforming Growth Factor beta Transforming Growth Factors |
| title | Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population |
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