Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population

We aim to investigate the long-term adverse effects of polycyclic aromatic hydrocarbons (PAHs) exposure on heart rate variability (HRV) reduction, and to assess the potential role of transforming growth factor-β1 (TGF-β1) in such relationship. We enrolled 2985 adult residents with 4100 observations...

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Veröffentlicht in:	Journal of hazardous materials 2022-03, Vol.425, p.127770-127770, Article 127770
Hauptverfasser:	Ma, Jixuan, Tan, Qiyou, Nie, Xiuquan, Zhou, Min, Wang, Bin, Wang, Xing, Cheng, Man, Ye, Zi, Xie, Yujia, Wang, Dongming, Chen, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Cardiovascular disease China Environmental pollutants Heart Rate HRV Humans PAHs Polycyclic Aromatic Hydrocarbons - toxicity TGF-β Transforming Growth Factor beta Transforming Growth Factors
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Beschreibung
Zusammenfassung:	We aim to investigate the long-term adverse effects of polycyclic aromatic hydrocarbons (PAHs) exposure on heart rate variability (HRV) reduction, and to assess the potential role of transforming growth factor-β1 (TGF-β1) in such relationship. We enrolled 2985 adult residents with 4100 observations who participated at baseline and 6-years follow-up from Wuhan-Zhuhai cohort. Ten detectable urinary PAHs metabolites and two HRV indices were repeatedly measured at baseline and follow-up; and plasma TGF-β1 levels were also determined for all subjects. We observed that both total urinary low molecular weight PAHs (ΣLWM OH-PAH) and total urinary high molecular weight PAHs (ΣHWM OH-PAH) were negatively associated with HRV reductions (P
ISSN:	0304-3894 1873-3336
DOI:	10.1016/j.jhazmat.2021.127770