TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm

To study the role of toll-like receptors 4-myeloid differentiation factor 88 (TLR4-Myd88) dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and explore the underlying pathogenic mechanisms. Lipopolysaccharide (LPS) and acetylcholine (Ach) were used to develop the in v...

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Veröffentlicht in:	Vascular pharmacology 2022-02, Vol.142, p.106947-106947, Article 106947
Hauptverfasser:	Zhao, Xin, Tian, Jinfan, Liu, Yue, Ye, Zhishuai, Xu, Mingyue, Huang, Rongchong, Song, Xiantao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Calcium Calcium ions Caveolin Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin-1 Coronary artery Coronary artery spasm Coronary vessels Coronary Vessels - metabolism Coronary Vessels - physiopathology EKG Electrocardiography Endothelial cells Endothelial dysfunction Fluorescence Human Umbilical Vein Endothelial Cells - metabolism Humans Immunofluorescence Inflammation Lipopolysaccharides Lipopolysaccharides - pharmacology Mice Microenvironments Mimicry Monitoring mRNA MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Nitrate reductase Reductases siRNA Spasm Telemedicine TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Umbilical vein
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Zusammenfassung:	To study the role of toll-like receptors 4-myeloid differentiation factor 88 (TLR4-Myd88) dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and explore the underlying pathogenic mechanisms. Lipopolysaccharide (LPS) and acetylcholine (Ach) were used to develop the in vitro and in vivo models mimicking the physiological CAS microenvironment. LPS-induced upregulation of Cav-1 expression in mouse coronary and aorta endothelial cells was shown by western blot and immunofluorescence (IF) staining (p
ISSN:	1537-1891 1879-3649
DOI:	10.1016/j.vph.2021.106947