para-Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-12, Vol.57 (97), p.13190-13193
Hauptverfasser: Zhu, Runqing, Sun, Qianqian, Li, Jing, Li, Luohao, Gao, Qinghe, Wang, Yakun, Fang, Lizhen
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Chemistry
Chemistry, Multidisciplinary
Ethers
Hydroxylation
Iodine
Physical Sciences
Ruthenium
Ruthenium compounds
Science & Technology
Substrates
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06210g