Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene
We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results sugges...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2021-12, Vol.58 (1), p.48-51 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 58 |
| creator | Sugimoto, Wataru Kinoshita, Natsuki Nakata, Minori Ohyama, Tatsuya Tateishi-Karimata, Hisae Nishikata, Takahito Sugimoto, Naoki Miyoshi, Daisuke Kawauchi, Keiko |
| description | We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the
gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results suggest an impact of neighboring sequences on the gene expression of guanine-rich sequences. |
| doi_str_mv | 10.1039/d1cc05523b |
| format | Article |
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gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. 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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2021-12, Vol.58 (1), p.48-51 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Competition Exons G-Quadruplexes GC Rich Sequence Gene expression Gene sequencing Humans Serine Endopeptidases - genetics |
| title | Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene |
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