Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene

Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene

We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results sugges...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-12, Vol.58 (1), p.48-51
Hauptverfasser: Sugimoto, Wataru, Kinoshita, Natsuki, Nakata, Minori, Ohyama, Tatsuya, Tateishi-Karimata, Hisae, Nishikata, Takahito, Sugimoto, Naoki, Miyoshi, Daisuke, Kawauchi, Keiko
Format: Artikel
Sprache:eng
Schlagworte:
Competition
Exons
G-Quadruplexes
GC Rich Sequence
Gene expression
Gene sequencing
Humans
Serine Endopeptidases - genetics
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Beschreibung
Zusammenfassung:We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results suggest an impact of neighboring sequences on the gene expression of guanine-rich sequences.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05523b