Functional MRI in assessment of diabetic kidney disease in people with type 1 diabetes

To compare levels of renal hypoxia measured by Blood Oxygen Level Dependent (BOLD) magnetic resonance imaging (MRI) with measured transverse relaxation rate (R2*) and renal structural changes including apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in patients with type 1 diabet...

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Veröffentlicht in:	Journal of diabetes and its complications 2022-01, Vol.36 (1), p.108076-108076, Article 108076
Hauptverfasser:	Seah, Jas-mine, Botterill, Elissa, MacIsaac, Richard J., Milne, Michele, Ekinci, Elif I., Lim, Ruth P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Biomarkers Cohort Studies Diabetes Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnostic imaging Diabetic kidney disease Diabetic Nephropathies - diagnostic imaging Diabetic nephropathy Diffusion Tensor Imaging - methods Glucose Hemoglobin Humans Hypoxia Kidney - diagnostic imaging Kidney diseases Magnetic resonance imaging Magnetic Resonance Imaging - methods MRI Neutrophils Renal biomarkers Statistical analysis
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Zusammenfassung:	To compare levels of renal hypoxia measured by Blood Oxygen Level Dependent (BOLD) magnetic resonance imaging (MRI) with measured transverse relaxation rate (R2*) and renal structural changes including apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in patients with type 1 diabetes and healthy controls. Cohort study comparing MRI metrics in type 1 diabetes (n = 32, GFR 105 (77, 120) ml/min.1.73m2) and controls (n = 10). Renal function and selected inflammatory renal biomarkers were also measured. For BOLD, we found reduced cortical [14.7 (13.7,15.8) (1/s) vs 15.7 (15.1,16.6) (1/s), p
ISSN:	1056-8727 1873-460X
DOI:	10.1016/j.jdiacomp.2021.108076